92446-10-1Relevant articles and documents
Synthesis and evaluation of a novel series of pseudo-cinnamic derivatives as antituberculosis agents
Yoya, Georges Koumba,Bedos-Belval, Florence,Constant, Patricia,Duran, Hubert,Daffe, Mamadou,Baltas, Michel
body text, p. 341 - 343 (2011/02/26)
In an effort to develop potent new antituberculous drugs effective against Mycobacterium tuberculosis, we have prepared series of cinnamic derivatives (thioesters and amides) with 4-hydroxy and 4-alkoxy groups and investigated the in vitro activities of these compounds. Among them some displayed a good in vitro antibacterial activity, such as (E)-N-(2-acetamidoethyl)-3-{4-[(E)-3,7-dimethylocta-2,6-dienyloxy]phenyl}acrylamide 4b that showed a minimum inhibitory concentration of 0.1 μg/mL (0.26 μM) against M. tuberculosis H37Rv.
NOUVELLE SYNTHESE DE PRECURSEURS PHENOLIQUES DES LIGNINES UTILISANT LES SELS D'IMINIUM DES ACIDES p-HYDROXY CINNAMIQUES
Duran, E.,Gorrichon, L.,Cazaux, L.,Tisnes, P.
, p. 2755 - 2758 (2007/10/02)
4-Hydroxy cinnamic esters, thiolesters, aldehydes and alcohols, or related compounds, implied in the biosynthesis of lignins are easily synthesized in good yields from iminium salts of coumaric 1a, ferulic 1b and sinapic 1c acids.No prior protection of the phenol group is needed in this method.