92486-75-4Relevant academic research and scientific papers
The Cyano Group as a Traceless Activation Group for the Intermolecular [3+2] Cycloaddition of Azomethine Ylides: A Five-Step Synthesis of (±)-Isoretronecanol
Li, Jundong,Zhao, Huaibo,Jiang, Xunjin,Wang, Xiance,Hu, Haiming,Yu, Lei,Zhang, Yandong
, p. 6306 - 6310 (2015)
The cyano group was used as a traceless activation group for the [3+2] cycloaddition of azomethine ylides in a two-step process, thereby providing a highly effective approach to 5-unsubstituted pyrrolidines. The transformation includes the silver acetate
A DyI3-catalyzed mannich-type reaction of 1- methylcyclopropanecarboxylate-type donors for the stereoselective synthesis of pyrrolidines with quaternary stereocenters
Noda, Hidetoshi,Wiedemann, Sean H.,Matsunaga, Shigeki,Shibasaki, Masakatsu
, p. 1180 - 1181 (2008)
Stereoselective synthesis of functionalized pyrrolidines with all-carbon quaternary stereocenters is described. DyI3 catalyzed the ring opening of cyclopropanecarboxylate equivalents and promoted Mannich-type addition of the resulting α,α-disub
WATER-INDUCED FORMATION OF AZOMETHINE YLIDE 1,3-DIPOLE. STEREOSPECIFIC AND REGIOSELECTIVE CYCLOADDITION REACTIONS
Tsuge, Otohiko,Kanemasa, Shuji,Hatada, Akira,Matsuda, Koyo
, p. 801 - 804 (2007/10/02)
An N-(trimethylsilylmethyl)imine generates the azomethine ylide 1,3-dipole of nonstabilized type, when treated with water, which cycloadds to olefinic dipolarophiles in a stereospecific and regioselective manner.
