57402-97-8

Upstream product

• 53215-95-5 N-(trimethylsilylmethyl)benzylamine 
• 18636-32-3 3-methyllumiflavin 
• 18166-02-4 N-trimethylsilylmethylamine 
• 100-52-7 benzaldehyde 
• 90606-07-8 <<(trimethylsilyl)methyl>imino>triphenylphosphorane 

Downstream Products

• 82959-86-2 (3aR,6aS)-2-Methyl-4-phenyl-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione 
• 82959-86-2 (3aS,6aR)-2-Methyl-4-phenyl-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione 
• 82959-86-2 2-methyl-4-phenyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione 
• 82959-86-2 2-methyl-4-phenyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione 
• 108303-98-6 N-benzyl-4-phenylpyrrolidin-2-one 
• 79962-72-4 1-Benzoyl-2-phenyl-pyrrolidine-3-carboxylic acid methyl ester 
• 79962-72-4 (2S,3S)-1-Benzoyl-2-phenyl-pyrrolidine-3-carboxylic acid methyl ester 
• 79962-72-4 (2S,3R)-1-Benzoyl-2-phenyl-pyrrolidine-3-carboxylic acid methyl ester 
• 79962-70-2 1-Benzoyl-2-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester 
• 344246-45-3 1-benzoyl-2,4-diphenyl-3-trimethylsilylmethylimidazolidine 
• 79962-67-7 1-Benzoyl-2-phenyl-2,5-dihydro-1H-pyrrole-3,4-dicarboxylic acid dimethyl ester 
• 51535-00-3 methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate 
• 82959-82-8 (3R,4R)-2-Phenyl-pyrrolidine-3,4-dicarboxylic acid dimethyl ester 
• 108303-96-4 2-({[1-Phenyl-meth-(E)-ylidene]-amino}-methyl)-succinic acid dimethyl ester 

Relevant academic research and scientific papers

NK1 ANTAGONIST

The invention is to a compound exhibiting neurokinin inhibitory properties, a pharmaceutical composition comprising same and a method of treatment for neurokinin-meditated conditions.Formula (I)

Amine-Flavin Electron Transfer Photochemistry. Potential Models for Monoamine Oxidase Catalysis and Inhibition

The photoreactions of 3-methyllumiflavin (3MLF) and a variety of amines have been explored.These studies have demonstrated that 3MLF undergoes efficient photoreactions with α-silyl tertiary benzylamines to generate 4a-adducts by pathways involving sequential SET and desilylation followed by radical coupling.These adducts are unstable substances that react rapidly with nucleophiles (e.g., MeOH, H2O, and NaBH4) and oxygen.Theyare also photolabile, providing the corresponding 4a-benzyldihydroflavin upon irradiation.Non-silicon-containing primary and secondary amines also participate in SET-promoted photoreactions with 3MLF.The amine cation radicals formed in these processes undergo further transformations to produce radical intermediates by either α-CH or NH deprotonation pathways.The potential relevance of these findings to the area of monoamine oxidase chemistry is considered.

AZOMETHINE YLIDE PRECURSORS: A SIMPLE ROUTE TO N-(TRIMETHYLSILYLMETHYL) IMINES

A simple synthesis of N-(trimethylsilylmethyl)amine is reported.This compounds was used to prepare N-(trimethylsilylmethyl)amines, useful sources of "nonstabilized" azomethine ylides.

Synthetic Versatility of N(Silylmethyl)imines: Water-Induced Generation of N-Protonated Azomethine Ylides of Nonstabilized Type and Fluoride-Induced Generation of 2-Azallyl Anions

N-(Silylmethyl)imines generate N-protonated azomethine ylides of nonstabilized type when treated with water in HMPA, which undergo stereospecific and regioselective cycloadditions with electron-poor olefins affording N-unsubstituted pyrrolidines.On the other hand, fluoride-induced desilylation of the imines leads to 2-azallyl anions which are found to be synthetic equivalents of aminomethyl anion in the Michael additions with electron-poor olefins and nucleophilic additions with carbonyl compounds.

1,3-Dipolar Cycloaddition Leading to N-Acylated Pyrrolidines and 2,5-Dihydropyrroles

Dipolar cycloaddition of an intermediary N-acyltrimethylsilylmethyliminium salt formed from N-(benzylidene)trimethylsilylmethylamine and acyl chloride to conjugated alkenes or alkines gave N-acylpyrrolidines or N-acyl-2,5-dihydropyrroles, respectively.The