924864-18-6Relevant articles and documents
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors
Shirai, Fumiyuki,Tsumura, Takeshi,Yashiroda, Yoko,Yuki, Hitomi,Niwa, Hideaki,Sato, Shin,Chikada, Tsubasa,Koda, Yasuko,Washizuka, Kenichi,Yoshimoto, Nobuko,Abe, Masako,Onuki, Tetsuo,Mazaki, Yui,Hirama, Chizuko,Fukami, Takehiro,Watanabe, Hirofumi,Honma, Teruki,Umehara, Takashi,Shirouzu, Mikako,Okue, Masayuki,Kano, Yuko,Watanabe, Takashi,Kitamura, Kouichi,Shitara, Eiki,Muramatsu, Yukiko,Yoshida, Haruka,Mizutani, Anna,Seimiya, Hiroyuki,Yoshida, Minoru,Koyama, Hiroo
, p. 3407 - 3427 (2019/04/17)
The canonical WNT pathway plays an important role in cancer pathogenesis. Inhibition of poly(ADP-ribose) polymerase catalytic activity of the tankyrases (TNKS/TNKS2) has been reported to reduce the Wnt/β-catenin signal by preventing poly ADP-ribosylation-
