92500-59-9

Upstream product

• 140-29-4 phenylacetonitrile 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 

Downstream Products

• 135351-42-7 2-[1,3]Dioxolan-2-ylmethyl-4,4-diethoxy-2-phenyl-butyronitrile 
• 106658-99-5 4,4-diethoxy-2-phenylbutan-1-amine 
• 99558-18-6 5-ethoxy-4,5-dihydro-3-phenylfuran-2(3H)-one 
• 27649-43-0 3-phenyl-1H-pyrrole 
• 53646-85-8 1,3-diphenyl-1H-pyrrole 
• 66515-33-1 2-phenylsuccinaldehyde 
• 85358-19-6 (2R,5R,8aS)-5-Methyl-2-phenyl-hexahydro-indolizin-7-one 
• 115114-08-4 (2R,5R,7S,8aS)-5-Methyl-2-phenyl-octahydro-indolizin-7-ylamine 
• 115114-04-0 (2α,5α,7α,8aβ)-4-amino-5-chloro-2-methoxy-N-(octahydro-5-methyl-2-phenylindolizin-7-yl)benzamide 
• 88897-71-6 (2R,7R,8aR)-2-Phenyl-octahydro-indolizin-7-ylamine 
• 88897-71-6 (2R,7S,8aS)-2-Phenyl-octahydro-indolizin-7-ylamine 
• 88897-67-0 (2R,8aR)-2-Phenyl-hexahydro-indolizin-7-one 
• 88897-67-0 (2R,8aS)-2-Phenyl-hexahydro-indolizin-7-one 
• 88897-72-7 (2S,8aS)-2-Phenyl-hexahydro-indolizin-7-one oxime 

Relevant academic research and scientific papers

A new synthesis of monosubstituted succinaldehydes and 3-substituted pyrroles from acetonitriles. Formal synthesis of 2,3-dihydro-7-methyl-2H-pyrrolizidin-1-one (Danaidone), a semiochemical of Danaid butterflies

A convenient and versatile synthesis of monosubstituted succinaldehydes and 3-substituted pyrroles from acetonitriles was devised. The methodology was applied to the preparation of 9, the penultimate intermediate in the Meinwald and Meinwald synthesis of Danaidone.12 Copyright

AN IMPROVED SYNTHESIS OF 4-SUBSTITUTED PYRIDINES FROM NITRILES

4-substituted pyridines have been prepared by a four-step sequence in 23-27percent overall yield from nitriles.

A facile synthesis of 3-substituted glutaraldehyde monacetals from nitriles

3-Substituted glutaraldehyde monoacetals 7 have been prepared in 48-58% overall yield, consecutively by the alkylation of nitriles, first with 2-bromo-1,1-diethoxyethane (2) and then with 2-iodomethyl-1,3-dioxolane (4), followed by removal of the cyano group and selective hydrolysis of the diethyl acetal function.

Substituted Benzamides with Conformationally Restricted Side Chains. 2. Indolizine Derivatives as Central Dopamine Receptor Antagonists

The substituted benzamides metoclopramide (1) and clebopride (3) are stimulants of gastric molitity.They are also central dopamine receptor antagonists with 3 being the more potent.This is presumed to be due to an additional interaction of its N-benzyl gr

Synthesis of Quinolizidines and Indolizidines via an Intramolecular Mannich Reaction

Acid treatment of the addition products (13) of an aminopentanal or aminobutanal diethyl acetal and an α,β-unsaturated ketone gave the quinolizidin-2-ones (11), (12), (20), (36), and (37) and the indolizidin-7-ones (9), (10), (16)-(19), (34), and (35) res

PREPARATION AND SOME REACTIONS OF 4- AND 5-ARYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONES

Efficient preparations of 4- and 5-phenyl-4,5-dihydropyridazin-3(2H)-ones have been developed, the main reactions of these compounds have been studied, and the synthetic routes have been used to give analogues with substituents in the phenyl rings.In the best synthesis of the 4-phenyldihyropyridazinone (72 percent overall yield) the product was obtained from phenylacetic acid by three simple stages.This approach was applied in preparations of the 2- and 4-hydroxyphenyl compounds and, in conjunction with a recent method for amine protection, the 4-aminophenyl analogue.A four stage synthesis starting from benzaldehyde gave the 5-phenyldihydropyridazinone in 47 percent overall yield; hydroxybenzaldehydes were similarly converted into 5-(allyloxyphenyl)dihydropyridazinones.Oxidation to phenylpyridazinones occured more readily with the 4- and 5-phenyldihydropyridazinones than with the 6-phenyl isomer.The 4- and 5-dihydropyridazinones were smoothly reduced to tetrahydropyridazinones by hydrogenation over platinum but were uneffected by palladium in the presence of hydrazine or cyclohexene.