66515-33-1

Upstream product

• 100-42-5 styrene 
• 68-12-2 N,N-dimethyl-formamide 
• 15463-92-0 dimethyl 2-phenylsuccinate 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 939-21-9 3-phenyl-4-pentenal 
• 635-51-8 2-phenylsuccinic acid 
• 140-29-4 phenylacetonitrile 
• 92500-59-9 α-(2,2-diethoxyethyl)benzyl cyanide 
• 34861-81-9 diethyl phenylsuccinate 

Downstream Products

• 27649-43-0 3-phenyl-1H-pyrrole 
• 938164-24-0 1-(2-bromo-4-methyl-phenyl)-3-phenyl-1H-pyrrole 
• 938164-25-1 1-(2-bromo-4-methyl-phenyl)-3-phenyl-1H-pyrrole-2-carbaldehyde 
• 3042-22-6 2-phenyl-1H-pyrrole 

Relevant academic research and scientific papers

Monoamine Oxidase-Catalyzed Oxidative Rearrangement of trans,trans-1-(Aminomethyl)-2-methoxy-3-phenylcyclopropane

trans,trans-1-(Aminomethyl)-2-methoxy-3-phenylcyclopropane (3) was synthesized in three steps from (Z)-β-methoxystyrene and ethyl diazoacetate. Compound 3 was shown to be a substrate and inactivator of mitochondrial beef liver monoamine oxidase (MAO) with

Synthesis of 1,3- and 1,2,3-functionalized pyrroles via Ir(I)-catalyzed vinylation of allyl alcohols

[Figure not available: see fulltext.] An efficient method for the preparation of 1,3-disubstituted and 1,2,3-trisubstituted pyrroles was developed through a sequence involving O-vinylation of allyl alcohols followed by Claisen rearrangement and further ozonolysis, concurring in a Paal–Knorr reaction with primary amines. Hg(II) and Ir(I) catalysts and different vinylating reagents were tested. The best results were consistently obtained with the [Ir(cod)Cl]2–vinyl acetate system. The featured methodology gives access to functionalized pyrroles in overall good yields, whose chemical architecture may awake interest for assorted applications.

Palladium-catalyzed annulation of aryl heterocycles with strained alkenes

An annulation reaction proceeding by the intermolecular addition of an arylpalladium(II) halide across a strained alkene, followed by an intramolecular C-H functionalization of a pendant heterocycle is described. A variety of polycyclic heterocycles have

Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators

This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alkylamide derivatives as bradykinin receptor agonists useful for the treatment of bradykinin modulated disorders such as hypertension and the like.

A new synthesis of monosubstituted succinaldehydes and 3-substituted pyrroles from acetonitriles. Formal synthesis of 2,3-dihydro-7-methyl-2H-pyrrolizidin-1-one (Danaidone), a semiochemical of Danaid butterflies

A convenient and versatile synthesis of monosubstituted succinaldehydes and 3-substituted pyrroles from acetonitriles was devised. The methodology was applied to the preparation of 9, the penultimate intermediate in the Meinwald and Meinwald synthesis of Danaidone.12 Copyright