92521-18-1

Basic information

• Product Name: 2-HYDROXY-4-PYRIDYLETHYLAMINE
• Synonyms: 2-AMINO-1-PYRIDIN-4-YL-ETHANOL;2-HYDROXY-4-PYRIDYLETHYLAMINE;2-AMINO-1-(4-PYRIDINYL)ETHANOL;2-AMINO-1-(4-PYRIDYL)ETHANOL;a-(aMinoMethyl)-4-PyridineMethanol;2-amino-1-(pyridin-4-yl)ethan-1-ol
• CAS NO: 92521-18-1
• Molecular Formula: C7H10N2O
• Molecular Weight: 138.17
• Product Categories: pharmacetical
• Mol File: 92521-18-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 57 °C
• Boiling Point: 130 °C(Press: 0.2 Torr)
• Appearance: /
• Density: 1.176±0.06 g/cm3(Predicted)
• PKA: 11.13±0.35(Predicted)
• CAS DataBase Reference: 2-HYDROXY-4-PYRIDYLETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-4-PYRIDYLETHYLAMINE(92521-18-1)
• EPA Substance Registry System: 2-HYDROXY-4-PYRIDYLETHYLAMINE(92521-18-1)

Safety Data

• Hazardous Substances Data: 92521-18-1(Hazardous Substances Data)

Usage

General Description

2-HYDROXY-4-PYRIDYLETHYLAMINE, also known as 4-Pyridylethanolamine, is a chemical compound that consists of a pyridine ring, a hydroxyl group, and an ethylamine side chain. It is a derivative of ethanolamine, and can be found naturally in the human body as a neurotransmitter. 2-HYDROXY-4-PYRIDYLETHYLAMINE has been studied for its potential role in modulating the central nervous system, as well as its effects on behavior and mood. Additionally, 2-HYDROXY-4-PYRIDYLETHYLAMINE has been investigated for its potential role in the treatment of various neurological and psychiatric disorders.

Upstream product

• 73286-33-6 4-(α-aminoacetyl)pyridine dihydrochloride 
• 1570-45-2 isonicotinic acid ethylester 
• 230977-07-8 2-hydroxyimino-3-oxo-3-(4-pyridyl)-propanoic acid ethyl ester 
• 26377-17-3 ethyl 3-oxo-3-(4-pyridyl)propanoate 
• 34064-35-2 4-(oxiran-2-yl)pyridine 
• 872-85-5 pyridine-4-carbaldehyde 
• 52239-23-3 rac-2-nitro-1-(pyridin-4-yl)ethan-1-ol 

Downstream Products

• 13258-63-4 4-(2-Aminoethyl)pyridine 
• 913642-43-0 rac-tert-butyl [2-hydroxy-2-(pyridin-4-yl)ethyl]carbamate 

Relevant articles and documents

Novel amide- and sulfonamide-based aromatic ethanolamines: Effects of various substituents on the inhibition of acid and neutral ceramidases

In the present study we describe the design and synthesis of a series of amide- and sulfonamide-based compounds as inhibitor of recombinant acid and neutral ceramidases. Inhibition of ceramidases has been shown to induce apoptosis and to increase the efficacy of conventional chemotherapy in several cancer models. B-13, lead in vitro inhibitor of acid ceramidase has been recently shown to be virtually inactive towards lysosomal acid ceramidase in living cells at lower concentrations and for a shorter time of treatment, suggesting the development of more potent inhibitors. In this study, a detailed SAR investigation has been performed to understand the effect of different substituents on the phenyl ring of amide- and sulfonamide-based compounds that partially resemble the structure of well-known inhibitors such as B-13, D-e-MAPP as well as NOE. Our results suggest that the electronic effects of the substituents on phenyl ring in B-13 and D-e-MAPP analogues have negligible effects either in enhancing the inhibition potencies or for selectivity towards aCDase over nCDase. However, the hydrophobicity and the steric effects of longer alkyl chains (n-Pr, n-Bu or t-Bu groups) at the phenyl ring were found to be important for an enhanced selectivity towards aCDase over nCDase.

3-heterocyclylpropanohydroxamic acid PCP inhibitors

Compounds of formula (I): and their salts, solvates, hydrates and prodrugs are useful PCP inhibitors, processes for making the same, compositions comprising the same, and methods of treating a PCP-mediated condition or disease using the same.