925453-62-9

Upstream product

• 1779-49-3 Methyltriphenylphosphonium bromide 
• 925453-22-1 tri-tert-butyl (1S,3S,4S,5R,6R,7R)-6-benzyloxy-7-(tert-butoxycarbonyl)oxy-1-(formylmethyl)-4-hydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylate 
• 1286209-82-2 C₃₆H₄₄O₁₄ 
• 1286209-89-9 C₂₉H₄₆O₁₃ 
• 100-39-0 benzyl bromide 
• 1286209-88-8 C₂₉H₄₄O₁₃ 
• 1286209-87-7 C₂₄H₃₆O₁₁ 
• 1286209-86-6 C₃₈H₄₄O₁₃ 
• 1286209-85-5 C₄₄H₅₈O₁₃Si 
• 1286209-84-4 C₅₁H₆₂O₁₅SSi 
• 1286209-83-3 C₄₄H₅₈O₁₄Si 
• 1204206-79-0 C₄₃H₅₀O₁₄ 

Downstream Products

• 644981-57-7 tri-tert-butyl [1S,1-(4S,5R),3S,4S,5R,6R,7R]-1-(4-acetoxy-5-methyl-6-phenyl-2-hexenyl)-6-benzyloxy-7-(tert-butoxycarbonyl)oxy-4-hydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylate 

Relevant academic research and scientific papers

A general access to zaragozic acids: Total synthesis and structure elucidation of zaragozic acidD and formal syntheses of zaragozic acidsA and C

One for all: The 2,8-dioxabicyclo[3.2.1]octane derivative 1 served as a general building block for the bioactive title compounds (see scheme; Bz=benzoyl, Bn=benzyl). Two chemoselective alkynylations and two ruthenium-catalyzed hydrogenations had key roles in the first total synthesis of zaragozic acidD, a potent ras-farnesyl protein transferase inhibitor. Copyright

Total syntheses of zaragozic acids A and C by a carbonyl ylide cycloaddition strategy

A carbonyl ylide cycloaddition approach to the squalene synthase inhibitors zaragozic acids A and C is described. The carbonyl ylide precursor 8 was synthesized starting from di-tert-butyl D-tartrate (47) via an eleven-step sequence involving the regiosel

Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C by a Carbonyl Ylide Cycloaddition Strategy

Ketal isomers avoided. The unique 2,8-dioxabicyclo[3.2.1 ]octane core of zaragozic acid C (1) was constructed in a Rh-catalyzed 1,3-dipolar cycloaddition of an alkyne to an ester carbonyl ylide. Another feature of this improved synthesis is the constructi