925458-11-3

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 866423-15-6 (R)-8-Benzyloxy-octan-2-ol 
• 866423-21-4 {(4S,5S)-5-[(R)-6-(tert-butyldiphenylsilyloxy)heptyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methanol 
• 866423-16-7 (7-benzyloxy-1-methyl-heptyloxy)-tert-butyl-diphenyl-silane 
• 866423-18-9 (E)-(R)-9-(tert-Butyl-diphenyl-silanyloxy)-dec-2-enoic acid ethyl ester 
• 866423-17-8 (R)-7-((tert-butyldiphenylsilyl)oxy)octan-1-ol 
• 866423-20-3 (4R,5S)-5-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-heptyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester 
• 866423-19-0 (2R,3S,9R)-9-(tert-Butyl-diphenyl-silanyloxy)-2,3-dihydroxy-decanoic acid ethyl ester 

Downstream Products

• 925458-13-5 (Z)-3-{(4S,5S)-5-[(R)-6-(tert-butyldiphenylsilyloxy)heptyl]-2,2-dimethyl[1,3]dioxolan-4-yl}acrylic acid 
• 851616-13-2 cladospolide B 
• 866423-22-5 (Z)-3-{(4S,5S)-5-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-heptyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-acrylic acid ethyl ester 

Relevant academic research and scientific papers

Stereoselective total synthesis of iso-cladospolide B

A simple and efficient stereoselective total synthesis of iso-cladospolide B and a formal total synthesis of cladospolide B, using Jacobsen's hydrolytic kinetic resolution, is described. Georg Thieme Verlag Stuttgart.

Efficient total synthesis of iso-cladospolide B and cladospolide B

An efficient synthesis of iso-cladospolide B and cladospolide B has been achieved using Jacobsen's hydrolytic kinetic resolution (HKR), Sharpless asymmetric dihydroxylation and Yamaguchi macrolactonization as the key steps.