866423-17-8

Upstream product

• 866423-15-6 (R)-8-Benzyloxy-octan-2-ol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 667419-30-9 (2R)-8-(4-methoxyphenylmethoxy)octan-2-ol 
• 162843-88-1 8-((4-methoxybenzyl)oxy)octan-1-ol 
• 1610046-41-7 (R)-tert-butyl((8-((4-methoxybenzyl)oxy)octan-2-yl)oxy)diphenylsilane 
• 629-41-4 1,8-Octanediol 
• 1610046-39-3 (S)-8-((4-methoxybenzyl)oxy)octane-1,2-diol 
• 1326775-56-7 8-((4-methoxybenzyl)oxy)octanal 
• 57618-47-0 5-benzyloxy-1-pentyne 
• 866423-16-7 (7-benzyloxy-1-methyl-heptyloxy)-tert-butyl-diphenyl-silane 

Downstream Products

• 1610046-44-0 (4R,10R)-10-(tert-butyldiphenylsilyloxy)undec-1-en-4-ylacrylate 
• 1610046-45-1 (R)-6-((R)-6-(tert-butyldiphenylsilyloxy)heptyl)-5,6-dihydro-2H-pyran-2-one 
• 851616-13-2 cladospolide B 
• 866423-20-3 (4R,5S)-5-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-heptyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid ethyl ester 
• 866423-19-0 (2R,3S,9R)-9-(tert-Butyl-diphenyl-silanyloxy)-2,3-dihydroxy-decanoic acid ethyl ester 
• 866423-21-4 {(4S,5S)-5-[(R)-6-(tert-butyldiphenylsilyloxy)heptyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methanol 
• 925458-11-3 (4S,5S)-5-[(R)-6-(tert-butyldiphenylsilyloxy)heptyl]-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde 
• 866423-18-9 (E)-(R)-9-(tert-Butyl-diphenyl-silanyloxy)-dec-2-enoic acid ethyl ester 

Relevant academic research and scientific papers

Total synthesis of greensporone C

The first total synthesis of greensporone C, a cytotoxic 14-membered resorcylic acid lactone, has been accomplished via a longest linear sequence of 16 steps in 3.3% overall yield. The key features of the synthesis include Mitsunobu esterification and ring-closing metathesis to construct the macrocycle and establish the (E)-olefin geometry, respectively. Our synthesis also confirmed the absolute stereochemistry of the natural product.

Total synthesis of antifungal gamahonolide A

The first stereoselective total synthesis of gamahonolide A (1) has been accomplished using aminoxylation, Keck allylation, and ring-closing metathesis (RCM) reactions as key steps.

Efficient total synthesis of iso-cladospolide B and cladospolide B

An efficient synthesis of iso-cladospolide B and cladospolide B has been achieved using Jacobsen's hydrolytic kinetic resolution (HKR), Sharpless asymmetric dihydroxylation and Yamaguchi macrolactonization as the key steps.