92552-01-7Relevant academic research and scientific papers
Chemoselective reduction of ?,￠-unsaturated carbonyl and carboxylic compounds by hydrogen iodide
Matsumoto, Shoji,Marumoto, Hayato,Akazome, Motohiro,Otani, Yasuhiko,Kaiho, Tatsuo
, p. 590 - 599 (2021/03/29)
The selective reduction of ?,￠-unsaturated carbonyl compounds was achieved to produce saturated carbonyl compounds with aqueous HI solution. The introduction of an aryl group at an ? or ￠ position efficiently facilitated the reduction with good yield. The reaction was applicable to compounds bearing carboxylic acids and halogen atoms. Through the investigation of the reaction mechanism, it was found that Michael-type addition of iodide occurred to produce ￠-iodo compounds followed by the reduction of C-I bond via anionic and radical paths.
PRODUCTION METHOD OF KETONE COMPOUND, AND PRODUCTION METHOD OF CARBOXYLIC ACID DERIVATIVE
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Paragraph 0043-0044, (2021/01/21)
PROBLEM TO BE SOLVED: To provide a production method of a ketone compound that is able to use a substrate unstable under a basic condition and perform selective reduction in a simple process by using hydriodic acid under an acidic condition. SOLUTION: A production method of a ketone compound is characterized by producing a ketone compound by mixing a α,β-unsaturated carbonyl compound and hydriodic acid under an acidic condition and heating the mixture at 80 to 150°C as shown by formula (1). (R1 is H, a monovalent aliphatic hydrocarbon that may be substituted, a C1 to C12 alkyl group of a straight or blanched chain that may be substituted, an aromatic group that may be substituted, a nonaromatic heterocyclic group that may be substituted, a carboxyl group, a hydroxy group, and an amino group; any one or more groups of R2 to R4 are an aromatic group, and the remainder is H, a substituted or unsubstituted monovalent aliphatic hydrocarbon, and a substituted or unsubstituted monovalent aromatic ring group.) SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
β-Iodo Ketones by Prevost Reaction of Vinyl Carbinols
Ciganek, Engelbert,Calabrese, J. C.
, p. 4439 - 4443 (2007/10/02)
Treatment of α-ethenyl-α-phenylbenzenemethanol with iodine and silver acetate in either acetic acid or benzene gave 1,2-diphenyl-3-iodo-1-propanone (6) in 85percent yield.Ring enlargements involving similar rearrangements were observed with a number of cy
