925643-44-3Relevant academic research and scientific papers
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors
Shirai, Fumiyuki,Tsumura, Takeshi,Yashiroda, Yoko,Yuki, Hitomi,Niwa, Hideaki,Sato, Shin,Chikada, Tsubasa,Koda, Yasuko,Washizuka, Kenichi,Yoshimoto, Nobuko,Abe, Masako,Onuki, Tetsuo,Mazaki, Yui,Hirama, Chizuko,Fukami, Takehiro,Watanabe, Hirofumi,Honma, Teruki,Umehara, Takashi,Shirouzu, Mikako,Okue, Masayuki,Kano, Yuko,Watanabe, Takashi,Kitamura, Kouichi,Shitara, Eiki,Muramatsu, Yukiko,Yoshida, Haruka,Mizutani, Anna,Seimiya, Hiroyuki,Yoshida, Minoru,Koyama, Hiroo
, p. 3407 - 3427 (2019)
The canonical WNT pathway plays an important role in cancer pathogenesis. Inhibition of poly(ADP-ribose) polymerase catalytic activity of the tankyrases (TNKS/TNKS2) has been reported to reduce the Wnt/β-catenin signal by preventing poly ADP-ribosylation-
TETRAHYDRO-QUINAZOLINONE DERIVATIVES AS TANK AND PARP INHIBITORS
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Page/Page column 57, (2013/08/28)
Compounds of the formula I in which U, V and W have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
