92573-18-7

Upstream product

• 92573-21-2 4-(ethoxycarbonylethylidene)-1-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole 

Downstream Products

• 155591-01-8 3-(p-toluenesulfonyl)-6,7,8,9-tetrahydro-3H-benzindol-8-one 
• 1027843-58-8 [1-(Toluene-4-sulfonyl)-1H-indol-4-yl]-acetyl chloride 
• 155591-00-7 1-(p-toluenesulfonyl)indol-4-acetic acid 

Relevant academic research and scientific papers

Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-Hydroxytryptamine-6 ligands

The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a CNS disorder related to or affected by the 5-HT6 receptor.

A FACILE SYNTHESIS OF 4-(CYANOMETHYL)INDOLES AND 4-(ETHOXYCARBONYL-METHYL)INDOLES FROM 5-HALO-4-OXO-4,5,6,7-TETRAHYDROINDOLES

4-(Cyanomethyl)indoles and 4-(ethoxycarbonylmethyl)-indoles were synthesized from 5-halo-4-oxo-4,5,6,7-tetrahydroindoles by means of Horner-Wittig reaction and succesive dehydrohalogenation.

SYNTHESIS OF 4-( CYANOMETHYLIDENE)- AND 4-( ETHOXYCARBONYLMETHYLIDENE)-4,5,6,7-TETRAHYDROINDOLES AND THEIR DEHYDROGENATION TO 4-( CYANOMETHYL)- AND 4-( ETHOXYCARBONYLMETHYL)INDOLES

The Horner-Wittig reaction of 4-oxo-4,5,6,7-tetrahydroindoles with (EtO)2P(O)CH2CN and (EtO)2P(O)CH2CO2Et yielded respectively 4-(cyanomethylidene)- and 4-(ethoxycarbonylmethylidene)-4,5,6,7-tetrahydroindoles, which were catalytically dehydrogenated to 4-