Bioorganic and Medicinal Chemistry Letters p. 2583 - 2586 (2002)
Update date:2022-08-04
Topics:
Gallant
Carriere
Chateauneuf
Denis
Gareau
Godbout
Greig
Juteau
Lachance
Lacombe
Lamontagne
Metters
Rochette
Ruel
Slipetz
Sawyer
Tremblay
Labelle
Potent and selective ligands for the human EP3 prostanoid receptor are described. Biaryl compounds bearing a tethered ortho substituted acidic moiety were identified as potent EP3 antagonists based on the SAR described herein. The binding affinity of key compounds on all eight human prostanoid receptors is reported.
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