92597-09-6

Upstream product

• 16524-13-3 (+/-)-N-benzoyl-trans-2-aminocyclohexane-carboxylic acid 
• 38778-78-8 ethyl 2-(benzylamino)cyclohex-1-ene-1-carboxylate 
• 63683-36-3 (1S,2R)-2-{[1-Phenyl-meth-(E)-ylidene]-amino}-cyclohexanecarboxylic acid 
• 100-52-7 benzaldehyde 
• 16524-13-3 (+/-)-cis-2-benzoylamino-cyclohexane carboxylic acid 
• 5691-20-3 (1RS,2SR)-2-aminocyclohexanecarboxylic acid 
• 38778-79-9 ethyl 2-(N-phenylamino)-1-cyclohexene-1-carboxylate 
• 50-00-0 formaldehyd 
• 71581-92-5 (+/-)-cis-N-Benzyl-2-(hydroxymethyl)cyclohexylamine 
• 71581-92-5 trans-2-(Benzylamino)-1-(hydroxymethyl)cyclohexane 

Relevant academic research and scientific papers

Chemo- and diastereoselective reduction of β-enamino esters: A convenient synthesis of both cis- and trans-γ-amino alcohols and β-amino esters

Convenient procedures for the chemo- and diastereoselective reduction of b-enamino esters 1 are described. Both cis- and trans-γ-amino alcohols 2 or b-amino esters 3 can be prepared by reduction of b-enamino esters 1, readily available starting materials, with the use of inexpensive reagents Na/i-PrOH or NaHB(OAc)3/AcOH, respectively, and the appropriate reduction conditions. The mechanisms and diastereoselectivities for the reductions are discussed. The relative configurations and conformations of the diastereoisomeric γ-amino alcohols 2 and β-amino esters 3 obtained are established by 1H and 13C NMR study and unequivocally set by their cyclic derivatives tetrahydro-1,3-oxazines 4.

STEREOCHEMICAL STUDIES-76 SATURATED HETEROCYCLES-63 SYNTHESIS OF CIS- AND TRANS-N-METHYL- AND N-BENZYL-4,5- AND 5,6-TETRAMETHYLENETETRAHYDRO-1,3-OXAZINES; AN X-RAY STUDY OF N-BENZYL-CIS-4,5-TETRAMETHYLENETETRAHYDRO-1,3-OXAZINIUM-PICRATE

The corresponding cis- and trans-N-methyl- and N-benzyl-5,6- and 4,5-tetramethylenetetrahydro-1,3-oxazines (5a,b-8a,b) were synthesized from cis- and trans-N-methyl- and N-benzyl-2-aminomethyl-1-cyclohexanols (1a,b,2 2a,b), and from cis- and trans-N-methy