926-25-0Relevant articles and documents
Synthetic method of aromatic aziridine cross-linking agent
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Paragraph 0032-0038, (2020/12/08)
The invention discloses a synthetic method of an aromatic aziridine cross-linking agent (figure 1). The method comprises three chemical synthesis steps: (I) reacting 1-amino-2-propanol with chlorosulfonic acid to obtain amino-isopropyl sulfate; (II) carrying out an intra-molecular nucleophilic substitution reaction on amino-isopropyl sulfate in alkali liquor, removing sulfate radical groups, and carrying out ring closing to generate an intermediate 2-methyl aziridine; and (III) directly reacting the obtained 2-methyl aziridine with isophthaloyl dichloride in a mixed system of alkali liquor andan organic solvent without separation, and carrying out separation and purification to obtain a final product 1,1'-(1,3-phthaloyl)bis(2-methyl-aziridine). The commodity name is HX-752, and the aromatic aziridine cross-linking agent has wide application. A liquid-liquid homogeneous or heterogeneous reaction is adopted, the reaction conditions are mild, the process is simple and easy to control, and the yield is high. Besides, the synthesis method has the advantages of fewer byproducts and low waste discharge amount, is suitable for large-scale production, and has favorable industrialization prospects.
An improved and mild wenker synthesis of aziridines
Li, Xinyao,Chen, Ning,Xu, Jiaxi
experimental part, p. 3423 - 3428 (2010/11/21)
The conventional Wenker synthesis of aziridines from vicinal amino alcohols has been modified by employing mild reaction conditions. Amino alcohols were converted into their hydrogen sulfates with chlorosulfonic acid. The sulfates were cyclized with sodium hydroxide, and even with non-nucleophilic sodium carbonate. The current, improved method extends the scope of the typical Wenker synthesis and is applicable to unstable amino alcohols in hot sulfuric acid and to unstable sulfates which favor elimination and hydroxide displacement in the presence of strong base. Georg Thieme Verlag Stuttgart.
A versatile synthesis of various substituted taurines from vicinal amino alcohols and aziridines
Chen, Ning,Jia, Weiyi,Xu, Jiaxi
experimental part, p. 5841 - 5846 (2010/03/03)
Taurine and structurally diverse substituted taurines have been synthesized by peroxyformic acid, oxidation of the thiazolidine-2-thione intermediates generated from, vicinal amino alcohols or aziridines and carbon disulfide. The stereochemistry and mechanisms of the reactions are disscussed. The method is a salt-free and versatile route, convenient in terms of purification, and can be used to synthesize optically active substituted taurines.
Expeditious and practical synthesis of various substituted taurines from amino alcohols
Zhang, Wei,Wang, Boyuan,Chen, Ning,Du, Da-Ming,Xu, Jiaxi
, p. 197 - 200 (2008/12/20)
Various substituted taurines have been synthesized expeditiously and practically in satisfactory to good yields directly from amino alcohols using a two-step, one-pot procedure, in which the amino alcohols undergo sulfuric acid esterification and subsequent sodium sulfite substitution. Treatment of amino-substituted secondary alcohols using the same procedure gave 2-substituted or 1,2-disubstituted taurines, indicating the formation of aziridines as intermediates during the substitution step. This method is one of the most efficient routes for preparing structurally diverse 2-substituted and 1,2- and 2,2-disubstituted taurines. Georg Thieme Verlag Stuttgart.
GENE DELIVERY MEDIATED BY LIPOSOME-DNA COMPLEX WITH CLEAVABLE PEG SURFACE MODIFICATION
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Page/Page column 31-32, (2008/06/13)
A liposome composition and method for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a cationic lipid and (ii) a lipid joined to a hydrophilic polymer by a releasable linkage. The liposomes are associated with a nucleic acid for delivery to a cell.
Gene delivery mediated by liposome-DNA complex with cleavable PEG surface modification
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, (2008/06/13)
A liposome composition and method for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a cationic lipid and (ii) a lipid joined to a hydrophilic polymer by a releasable linkage. The liposomes are associated with a nucleic acid for delivery to a cell.
Liposome composition for delivery of nucleic acid
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, (2008/06/13)
A liposome composition for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a lipid that is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH and (ii) a lipid joined to a hydrophilic polymer by a dithiobenzyl linkage. The liposomes are associated with a nucleic acid for delievery to a cell.
Releasable linkage and compositions containing same
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, (2008/06/13)
A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described.
Synthesis and Insecticidal Activity of Oxazaphospholidines, Oxathiaphospholanes, and Thiazaphospholidines
Wu, Shao-Yong,Hirashima, Akinori,Takeya, Ryuko,Eto, Morifusa
, p. 2911 - 2918 (2007/10/02)
Fifty-five new five-membered cyclic organophosphorus compounds including oazaphospholidines, thiazaphospholidines, and oxathiaphospholanes were synthesized, which have substituents at 4- or/and 5-positions besides at the 2-position.The thiazaphospholidines showed the highest insecticidal activity followed by oxathiaphospholanes and oxazaphospholidines.The position preference of substituents in insecticidal activity was most obvious in the oxazaphospholidines.It was preferable for insecticidal activity to have the substituent near the more basic atom: the 4-position for thiazaphospholidine and oxazaphospholidine, the 5-position for oxathiaphospholane, with the exception of 4- or 5-phenyl oxazaphospholidine.
