926309-10-6

Basic information

• Product Name: D-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester
• Synonyms: D-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester;isopropyl(chloro(phenoxy)phosphoryl)-D-alaninate;EOS-61182
• CAS NO: 926309-10-6
• Molecular Formula: C₁₂H₁₇ClNO₄P
• Molecular Weight: 305.694441
• Mol File: 926309-10-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 376.5±44.0 °C(Predicted)
• Appearance: /
• Density: 1.249±0.06 g/cm3(Predicted)
• PKA: -6.04±0.70(Predicted)
• CAS DataBase Reference: D-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: D-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester(926309-10-6)
• EPA Substance Registry System: D-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester(926309-10-6)

Safety Data

• Hazardous Substances Data: 926309-10-6(Hazardous Substances Data)

Usage

General Description

D-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester is a chemical compound used in the synthesis of various pharmaceuticals, particularly in the production of antibiotics and antimicrobial agents. It is an ester of D-alanine, an amino acid commonly found in bacterial cell walls, and exhibits antimicrobial properties owing to its ability to disrupt cell wall synthesis in bacteria. D-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester is also used in research and development of new drugs and therapies for bacterial infections. Overall, D-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester plays a crucial role in the pharmaceutical industry and holds potential for the treatment of various bacterial diseases.

Upstream product

• 770-12-7 O-phenyl phosphorodichloridate 
• 39613-92-8 (R)-1-isopropoxy-1-oxopropan-2-aminium chloride 

Downstream Products

• 1627824-09-2 isopropyl (2R)-2-[[(2,3,4,5,6-pentafluorophenoxy)-phenoxy-phosphoryl]amino]propanoate 
• 1496551-77-9 MK-3682 
• 1496551-77-9 ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-chloro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alanine isopropyl ester 
• 1496552-16-9 ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alanine isopropyl ester 

Relevant articles and documents

PROCESS FOR MAKING CHLORO-SUBSTITUTED NUCLEOSIDE PHOSPHORAMIDATE COMPOUNDS

The present invention is directed to a process for making Chloro-Substituted Nucleoside Phosphoramidate Compounds of formula (I): which are useful for the treatment and prophylaxis of HCV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).

1',4'-THIO NUCLEOSIDES FOR THE TREATMENT OF HCV

Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 1′,4′-thio nucleoside compounds which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. In certain embodiments, the compounds are of Formula 3001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof; wherein Base, RA, RB, W, X, Y, and Z are as described herein.