1496552-16-9

Basic information

• Product Name: D-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester
• Synonyms: D-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester;isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate;Sofosbuvir impurity A
• CAS NO: 1496552-16-9
• Molecular Formula: C22H29FN3O9P
• Molecular Weight: 529.4525242
• Mol File: 1496552-16-9.mol
• Article Data: 53

Chemical Properties

• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• PKA: 9.39±0.10(Predicted)
• CAS DataBase Reference: D-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: D-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester(1496552-16-9)
• EPA Substance Registry System: D-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester(1496552-16-9)

Safety Data

• Hazardous Substances Data: 1496552-16-9(Hazardous Substances Data)

Usage

General Description

"D-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester" is a complex organic compound consisting of a variety of chemical functionalities. Its structure includes a D-Alanine residue, an essential amino acid found in proteins. The mention of '2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl' signifies the presence of a modified uridine nucleotide with a methyl and fluorine substituents. The '1-Methylethyl ester' moiety indicates it is an ester derivative, likely serving as a protective group for the carboxylic acid function of the D-Alanine. D-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester is possibly a synthetic intermediate in manufacturing spicific pharmaceuticals or substances for biochemical research, although more information would be needed to confirm its specific uses and properties.

Upstream product

• 39825-33-7 isopropyl L-alanine 
• 770-12-7 O-phenyl phosphorodichloridate 
• 863329-66-2 2'-deoxy-2'-fluoro-2'-methyluridine 
• 1256490-52-4 (S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester 
• 2041584-99-8 1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 
• 39613-92-8 alanine isopropyl ester hydrochloride 
• 1627824-09-2 isopropyl (2R)-2-[[(2,3,4,5,6-pentafluorophenoxy)-phenoxy-phosphoryl]amino]propanoate 
• 677299-16-0 (2R,3R,4R)-3,4-bis((2,4-dichlorobenzyl)oxy)-2-(((2,4-dichlorobenzyl)oxy)methyl)-5-methoxytetrahydrofuran 
• 926309-10-6 isopropyl (2R)-2-((chloro(phenoxy)phosphoryl)amino)propanoate 
• 1627824-09-2 (R)-2-((R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino)propionic acid isopropyl ester 
• 1334513-02-8 (S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester 
• 261909-49-3 phenyl(isopropoxy-L-alaninyl) phosphorochloridate 
• 2041584-99-8 1-[(2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-3-methyltetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione 
• 443642-31-7 (2S,3R,4R,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-ol 

Relevant articles and documents

Preparation method of anti-HCV medicine

The invention relates to the technical field of medical intermediates, in particular to a preparation method of an anti-HCV drug, which comprises the following steps: 1) reacting a compound I with a compound II in the presence of Lewis acid and alkali to obtain a compound III; and 2) reacting the compound III with a compound IV to obtain a compound V. The method effectively solves the problems of tedious steps, difficulty in purification, high cost and the like in the prior art. Meanwhile, the whole route is mild in reaction condition, convenient to operate, high in yield and purity and suitable for industrial large-scale production.

Method for preparing sofosbuvir

The invention discloses a method for preparing sofosbuvir. The method comprises the following steps: reacting tetrahydrofuran with a tetrahydrofuran solution of a material A, a material B, DMAP and ananiline compound under the protection of nitrogen, and monitoring the reaction by TLC until the reaction of the material A is finished, wherein the aniline compound is N,N-dimethylaniline or N,N-diethylaniline; and carrying out post-treatment on the obtained reaction product. The method for preparing sofosbuvir has the advantages of high reaction efficiency, high product yield (up to 90% or above), high purity (up to 98% or above), easiness in industrial large-scale production and great application values.

Method for synthesizing Sofosbuvir

The invention discloses a method for synthesizing Sofosbuvir. The method comprises the steps of adding a compound 1, a compound 2 and dichloromethane into a reaction bulb, cooling the temperature to 0DEG C, then, adding aluminum chloride, adding a proper amount of pyridine, and carrying out a reaction at a reaction temperature of 15 DEG C to 20 DEG C, thereby producing the Sofosbuvir. According to the method, the reaction is high in conversion ratio and good in regioselectivity and stereoselectivity, so that the synthesis cost of the Sofosbuvir is reduced, and the method has remarkable socialand economic benefits.