92669-91-5

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 91-16-7 1,2-dimethoxybenzene 

Downstream Products

• 92669-92-6 1,4-bis(trimethylsilyl)-2,3-dimethoxybenzene 
• 51560-25-9 1,4-diiodo-2,3-dimethoxybenzene 
• 361525-84-0 1,4-diiodo-2,3-dihydroxybenzene 
• 378233-26-2 1,4-diiodo-2,3-di(n-dodecyloxy)benzene 
• 1432489-09-2 C₂₆H₂₄O₈ 
• 1432489-10-5 C₂₈H₂₈O₉ 
• 1612854-20-2 C₅₁H₅₈N₈O₉ 
• 1612854-19-9 C₃₁H₃₅IN₄O₅ 
• 25245-33-4 1-iodo-2,3-dimethoxybenzene 

Relevant academic research and scientific papers

A rings-in-pores net: Crown ether-based covalent organic frameworks for phase-transfer catalysis

We herein present a new family of crown ether-based covalent organic frameworks (CE-COFs) for the first time. The CE-COFs show excellent phase-transfer catalytic performance in various nucleophilic substitution reactions.

SPIRO COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS

Disclosed are spiro compounds of formula (I), or stereomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof. The compounds can be used to treat hepatitis C virus (HCV) infection or hepatitis C disease. Furthermore disclosed are pharmaceutical compositions containing the compounds and the method of using the compounds or pharmaceutical compositions in the treatment of HCV infection or hepatitis C disease.

SPIRO RING COMPOUND AS HEPATITIS C VIRUS (HCV) INHIBITOR AND USES THEREOF FIELD OF THE INVENTION

A compound of formula (I) or a stereoisomer, a geometric isomer. a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof is provided, which can be used for treating HCV infection or a HCV disorder. Also a pharmaceutical composition comprising the compound and the use of the compound and the pharmaceutical composition thereof are provided, which can also be used for treating HCV infection or a HCV disorder.

Distinct interpenetrated metal-organic frameworks constructed from crown ether-based strut analogue

Rigid struts containing crown ether units (benzo-12-crown-4 and benzo-15-crown-5) coordinate with Zn4O(CO2)6 clusters, affording two different interpenetrated metal-organic frameworks (MOFs), i.e., benzo-12-crown-4-based MOF presents a "close contact" interpenetration mode, while the benzo-15-crown-5-based one has a "body center" interpenetration mode.

Catechol-based macrocyclic rods: En route to redox-active molecular switches

The design and synthesis of the macrocyclic turnstile 1 comprising a terminally sulfur-functionalized molecular rod and a redox-active catechol subunit is described, The shape-persistent macrocyclic scaffold consists of alternating arylene and ethynylene

Rigid-Strut-Containing crown ethers and [2]catenanes for incorporation into Metal-Organic frameworks

To introduce crown ethers into the struts of metal - organic frameworks (MOFs), general approaches have been developed for the syntheses of dicarboxylic acid dibenzo[30]crown-10 (DB30C10DA), dicarboxylic acid di-2,3-naphtho[30] crown-10 (DN30C10DA), dicarboxylic acid bisparaphenylene[34]crown-10 (BPP34C10DA), and dicarboxylic acid 1, 5-naphthoparaphenylene[36]crown-10 (NPP36C10DA). These novel crown ethers not only retain the characteristics of their parent crown ethers since they can 1) bind cationic guests and 2) serve as templates for making mechanically interlocked molecules (MIMs), such as catenanes and rotaxanes, but they also present coordination sites to connect with secondary building units (SBUs) in MOFs. The binding behavior of BPP34C10DA with 1,1′-dimethy 1-4, 4′-bipyridinium bis(hexafluorophosphate) (DMBP·2PF6) has been investigated by means of UV/ Vis, fluorescence, and NMR spectroscopic techniques. The crystal superstructure of the complex DMBP·2PF6C BPP34C10DA was determined by X-ray crystallography. The NPP36C10DA-based [2]catenane (H 2NPP36C10DC·CAT4PFfi) and the BPP34C10DA-based [2]catenane (H2BPP34C10DC-CAT-4PF6) were prepared in DMF at room temperature by the template-directed clipping reactions of the planarly chiral NPP36C10DA and BPP34C10DA with 1, 1′-[1,4-phenylenebis(methylene)]di4, 4′-bipyridin-l-ium bis(hexafluorophosphate) and 1,4-bis(bromomethyl) benzene, respectively. The crystal structure of the dimethyl ester (BPP34C10DE-CAT·4PF6) of the [2]catenane H 2BPP34C10DC-CAT·4PF6 was investigated by X-ray crystallography, which revealed racemic R and S isomers with planar chirality present in the crystal in a 1:1 ratio. These crown ether based struts serve as excellent organic ligands to bind with transition metal ions in the construction of MOFs: the crown ethers BPP34C10DA and NPP36C10DA in the presence of Zn(NO3)2·4H2O afforded the MOF-1001 and MOF-1002 frameworks, respectively. The crystal structures of MOF-1001 and MOF-1002 are both cubic and display Fm3m symmetry. The unit cell parameter of the metal - organic frameworks is α= 52.9345 A. Since such MOFs, containing electron-donating crown ethers are capable of docking incoming electronaccepting substrates in a stereoelectronically controlled fashion, the present work opens a new access to the preparation and application of MOFs.

Metalation in hydrocarbon solvents: The mechanistic aspects of substrate-promoted ortho-metalations

The methoxy-substituted aromatic reagents 1,2- and 1,3-dimethoxybenzene (1,2-DMB and 1,3-DMB) and 1,2,4-trimethoxybenzene (1,2,4-TMB) each undergo directed ortho-metalation in high yield in n-BuLi/hydrocarbon media without the aid of a catalyst. These rea

Conjugated polymers containing 2,3-dialkoxybenzene and iptycene building blocks

(matrix presented) New poly(phenylene ethynylene)s (PPEs) and poly(phenylene vinylene)s (PPVs) that are highly emissive in solution and thin films were prepared utilizing palladium-catalyzed cross-coupling between new 1,4-diiodo-2,3-dialkoxybenzene- and i

Ortho-metallation of anthracene derivative: Problem and solution

Ortho-metallation of anthracene derivative with alkyllithium is hampered by the preferential attack of the anion to the C(9) and/or C(10) positions. Use of n-BuLi-t-BuOK effected a clean and regioselective metallation at C(2) and subsequent reaction with

Dilithiation of Aromatic Ethers

The lithiations of anisole and all the isomeric dimethoxy- and trimethoxybenzenes with 2-5 equiv of n-butyllithium/TMEDA complex have been investigated under a variety of reaction conditions.Anisole and m-dimethoxybenzene do not undergo dilithiatian, but