927-55-9

Usage

Chemical Properties

Pale Yellow Low Melting Solid

InChI:InChI=1/C5H13NO/c1-5(6)3-2-4-7/h5,7H,2-4,6H2,1H3

Upstream product

• 1071-73-4 5-Hydroxy-2-pentanone 
• 57669-08-6 5-hydroxypentan-2-one oxime 
• 4093-53-2 4-nitro-valeric acid ethyl ester 
• 74-80-6 pentyl hydroperoxide 
• 10312-37-5 methyl 4-nitropentanoate 

Downstream Products

• 64992-33-2 N-(4-hydroxy-1-methyl-butyl)-phthalimide 
• 10500-64-8 4-(7-chloro-quinolin-4-ylamino)-pentan-1-ol 
• 4298-15-1 Cletoquine 
• 1356009-48-7 5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-amine 
• 1356009-59-0 tert-butyl (5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-yl)carbamate 
• 1356008-77-9 18-(2,4-difluorophenyl)-13-methyl-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-3H-15,2-(azeno)-4,8-(metheno)cyciopenta[h][1,6,10,12]oxatriazacycloheptadecine 
• 1356010-60-0 N-(5-(5-amino-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)pentan-2-yl)-2-chloro-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine 
• 1356009-99-8 2-chloro-7-(2,4-difluorophenyl)-N-(5-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)pentan-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine 
• 179412-96-5 tert-butyl (4-hydroxy-1-methylbutyl)carbamate 
• 804440-41-3 Benzilsaeure-({2-[aethyl-(4-chlor-1-methyl-butyl)-amino]-aethylester}) 
• 98131-27-2 Benzilsaeure-<<2--aethylester>> 
• 58554-66-8 N-(4-bromo-1-methyl-butyl)-phthalimide 
• 765-38-8 2-methyl-1-pyrrolidine 

Relevant academic research and scientific papers

SMALL MOLECULE INHIBITORS OF AUTOPHAGY AND HISTONE DEACTYLASES AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinoline or thioxanthenone (or similar) structure which function as autophagy inhibitors and/or histone deactylase inhibitors, and their use as therapeutics for the treatment of conditions characterized with aberrant autophagy activity and/or aberrant HDAC activity (e.g., cancer, pulmonary hypertension, diabetes, neurodegenerative disorders, aging, heart disease, rheumatoid arthritis, infectious diseases, conditions and symptoms caused by a viral infection (e.g., COVID-19)).

Reductive amination of bio-based 2-hydroxytetrahydropyran to 5-Amino-1-pentanol over nano-Ni-Al2O3catalysts

The synthesis of useful amines from bio-based carbonyl compounds is highly desired owing to their mild reaction conditions and green sustainability. The reductive amination of bio-furfural-derived 2-hydroxytetrahydropyran (2-HTHP) to high-value-added 5-Amino-1-pentanol (5-AP) was carried out over efficient Ni-Al2O3catalysts prepared by a co-precipitation method. Among the Ni-Al2O3catalysts with different Ni loadings (0-100 wt%) tested, the 50Ni-Al2O3catalyst exhibited the highest5-APyield of 91.3% under mild conditions of 60 °C and 2 MPa H2. This catalyst also presented good stability during a 150 h time-on-stream without appreciable deactivation. Characterization results showed that the 50Ni-Al2O3catalyst exhibited small Ni0nanoparticles (5.5 nm), a high reduction degree (up to 95%), and a large amount of strong Lewis acid sites. The cooperative catalysis of the strong Lewis acid sites and highly dispersed metallic Ni sites is suggested to play an important role in achieving high efficiency in2-HTHPreductive amination.

APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS AND USES THEREOF

Described herein are ASK1 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of blood disease, autoimmune disorders, pulmonary disorders, hypertension, inflammatory diseases, fibrotic diseases, diabetes, diabetic nephropathy, renal diseases, respiratory diseases, cardiovascular diseases, acute lung injuries, acute or chronic liver diseases, and neurodegenerative diseases.

FUNCTIONALIZATION OF THE δ-CARBON ATOM BY THE FERROUS ION INDUCED DECOMPOSITION OF ALKYL HYDROPEROXIDES IN THE PRESENCE OF CUPRIC SALTS

In the ferrous ion induced decomposition of alkyl hydroperoxides in the presence of cupric halides or pseudohalides, intramolecular functionalization with ligand transfer from cupric salts to δ-carbon atom, is achieved.