927-92-4

Basic information

• Product Name: heptane-1-sulfonyl chloride
• Synonyms: 1-heptanesulfonyl chloride
• CAS NO: 927-92-4
• Molecular Formula: C₇H₁₅ClO₂S
• Molecular Weight: 198.7108
• Mol File: 927-92-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 258.9°C at 760 mmHg
• Flash Point: 110.4°C
• Density: 1.125g/cm³
• Vapor Pressure: 0.0216mmHg at 25°C
• Refractive Index: 1.457
• CAS DataBase Reference: heptane-1-sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: heptane-1-sulfonyl chloride(927-92-4)
• EPA Substance Registry System: heptane-1-sulfonyl chloride(927-92-4)

Safety Data

• Hazardous Substances Data: 927-92-4(Hazardous Substances Data)

Upstream product

• 142-82-5 n-heptane 
• 60586-80-3 heptane-1-sulfonic acid 
• 10026-13-8 phosphorus pentachloride 
• 629-04-9 1-Bromoheptane 
• 22767-50-6 sodium heptanesulfonate 
• 7782-50-5 chlorine 
• 1639-09-4 heptanethiol 
• 629-06-1 1-Chloroheptane 

Downstream Products

• 100337-54-0 Aethyl-4-heptansulfonamidobenzoat 
• 88413-12-1 N-<3-(methylamino)-4-nitrophenyl>heptanesulfonamide 
• 88412-83-3 Heptane-1-sulfonic acid [4-(acridin-9-ylamino)-3-methylamino-phenyl]-amide 
• 335-71-7 perfluoroheptane sulfonylfluoride 
• 57603-96-0 heptane-1-sulfonamide 
• 97213-15-5 (4-Heptansulfonamidobenzoyl)hydrazin 

Relevant articles and documents

Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis

8-Nitrobenzothiazinones (BTZs) are a promising class of antimycobacterial agents currently under investigation in clinical trials. Starting from thiourea derivatives, a new synthetic pathway to BTZs was established. It allows the formation of the thiazinone ring system in one synthetic step and is applicable for preparation of a wide variety of BTZ analogues. The synthetic procedure furthermore facilitates the replacement of the sulphur atom in the thiazinone ring system by oxygen or nitrogen to afford the analogous benzoxazinone and quinazolinone systems. 36 BTZ analogues were prepared and tested in luminescence-based assays for in vitro activity against Mycobacterium tuberculosis (Mtb) using the microdilution broth method and a high-throughput macrophage infection assay.

Sulfonyl halide synthesis by thiol oxyhalogenation using NBS/NCS – iPrOH

A rapid and facile method provides a general route to sulfonyl bromides/chlorides by the oxidation of thiols using NXS – ROH (X?=?Br,Cl, R?=?iPr) as an oxyhalogenation reagent. Control experiments suggest that the alcohol component is the source of oxygen. The proposed method enable the access to structurally diverse sulfonyl bromides and chlorides including challenging examples, inaccessible by other synthetic methods.

N-Sulfonyl homoserine lactones as antagonists of bacterial quorum sensing

A series of 11 N-sulfonyl homoserine lactones has been synthesised. Some of them were found to competitively inhibit the action of 3-oxohexanoyl-L- homoserine lactone, the natural inducer of bioluminescence in the bacterium Vibrio fischeri. Molecular modeling suggests a possible explanation based on the prevention of structural rearrangements necessary for the formation of the active dimer of LuxR.