92713-19-4

Upstream product

• 1195-45-5 para-fluorophenyl isocyanate 
• 56-40-6 glycine 
• 1146299-64-0 methyl 2-(3-(4-fluorophenyl)ureido)acetate 
• 371-40-4 4-fluoroaniline 
• 345648-33-1 [3-(4-Fluoro-phenyl)-ureido]-acetic acid 4'-{2-[3-(4-fluoro-phenyl)-ureido]-acetoxymethyl}-[2,2']bipyridinyl-4-ylmethyl ester 

Downstream Products

• 1020535-80-1 N-(3-fluoro-4-(2-(pyrrolidine-1-carboxamido)pyridin-4-yloxy)phenyl)-3-(4-fluorophenyl)-2,4-dioxoimidazolidine-1-carboxamide 
• 1174133-46-0 1-[2-(4-chlorophenoxy)propanoyl]-3-(4-fluorophenyl)imidazolidine-2,4-dione 
• 1174133-43-7 1-[2-(2,4-dichlorophenoxy)propanoyl]-3-(4-fluorophenyl)imidazolidine-2,4-dione 
• 1174133-49-3 1-[2-(4-fluorophenoxy)propanoyl]-3-(4-fluorophenyl)imidazolidine-2,4-dione 
• 1174133-40-4 3-(4-fluorophenyl)-1-(2-phenoxypropanoyl)imidazolidine-2,4-dione 
• 1198160-01-8 (Z)-3-(4-fluorophenyl)-5-(3-ethoxy-4-hydroxybenzylidene)imidazolidine-2,4-dione 
• 1446483-87-9 5-((dimethylamino)methylene)-3-(4-fluorophenyl)imidazolidine-2,4-dione 

Relevant academic research and scientific papers

Discovery of hybrid dual N-acylhydrazone and diaryl urea derivatives as potent antitumor agents: Design, synthesis and cytotoxicity evaluation

Based on the hybrid pharmacophore design concept, a novel series of dual diaryl urea and N-acylhydrazone derivatives were synthesized and evaluated for their in vitro cytotoxicity by the standard MTT assay. The pharmacological results indicated that most compounds exhibited moderate to excellent activity. Moreover, compound 2g showed the most potent cytotoxicity against HL-60, A549 and MDA-MB-231 cell lines, with IC50 values of 0.22, 0.34 and 0.41 μM, respectively, which was 3.8 to 22.5 times more active than the reference compounds sorafenib and PAC-1. The promising compound 2g thus emerges as a lead for further structural modifications.

INHIBITORS OF BACTERIAL BIOFILM FORMATION

Organic compounds are described for use in inhibiting or preventing formation of bacterial biofilms.

Synthesis and herbicidal activity of 3-aryl-1-[2-(aryloxy)propanoyl] imidazolidine-2,4-diones

(Chemical Equation Presented) A series of novel 3-aryl-1-[2-(aryloxy) propanoyl]imidazolidine-2,4-diones were synthesized by the condensation of 3-aryl-imidazolidine-2,4-diones with 2-(aryloxy)propanoyl chlorides under mild conditions. Their structures we

KINASE INHIBITORS AND USES THEREOF

The present invention relates to compounds of the general formula (A) and pharmaceutical compositions thereof that inhibit protein tyrosine activity. In particular the invention relates to said compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signalling, for example, the inhibition of VEGF receptor signalling and HGF receptor signalling. Said compounds and compositions are useful for the treatment of cell proliferative diseases and conditions.

A new phase-switch method for application in organic synthesis programs employing immobilization through metal-chelated tagging

Simple purification of compounds can be achieved using a bipyridine unit as a tag and resin-bound metal ions. The usefulness of this method (see scheme) is demonstrated by the multistep synthesis of a small library of hydeantoins and benzodiazepines.