92736-35-1

Basic information

• Product Name: 2-Quinazolinecarbonitrile, 1,2-dihydro-4-methyl-1-(4-nitrobenzoyl)-
• CAS NO: 92736-35-1
• Molecular Formula: C17H12N4O3
• Molecular Weight: 320.307
• Mol File: 92736-35-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Quinazolinecarbonitrile, 1,2-dihydro-4-methyl-1-(4-nitrobenzoyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Quinazolinecarbonitrile, 1,2-dihydro-4-methyl-1-(4-nitrobenzoyl)-(92736-35-1)
• EPA Substance Registry System: 2-Quinazolinecarbonitrile, 1,2-dihydro-4-methyl-1-(4-nitrobenzoyl)-(92736-35-1)

Safety Data

• Hazardous Substances Data: 92736-35-1(Hazardous Substances Data)

Upstream product

• 5257-06-7 N-(2-acetylphenyl)formamide 
• 700-46-9 4-methylquinazoline 
• 7677-24-9 trimethylsilyl cyanide 
• 122-04-3 4-nitro-benzoyl chloride 

Relevant articles and documents

STUDIES WITH REISSERT COMPOUNDS. PART 17. MONO-REISSERT COMPOUND FORMATION AT THE 1,2-POSITION OF THE QUINAZOLINE SYSTEM.

4-Substituted quinazolines have been selectively converted into mono-Reissert compounds at the 1,2-position by use of acid chlorides and trimethylsilyl cyanide.Various reactions of the quinazoline Reissert compounds are reported.For example, conjugate base generation at the 2-position leads to a 1,2-rearrangement, whereas substitution occurs in the presence of an alkyl halide, providing, after hydrolysis, 2-alkyl-4-phenylquinazolines in good yield.Ring annellation by intramolecular alkylation is also reported.The quinazoline Reissert compound conjugate base reacts with aldehydes to give alcohol esters which can further be converted, via the alcohol and use of phosgene, to novel oxazoloquinazoline derivatives.