128217-62-9

Upstream product

• 102831-44-7 diethyl tert-butoxycarbonylaminomalonate 
• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 
• 1313214-06-0 N-(tert-butoxycarbonyl)-3,4-(dihydroxy)-L-phenylalanine ethyl ester 
• 74-88-4 methyl iodide 
• 1421282-28-1 N-(tert-butoxycarbonyl)-3,4-dimethoxy-6-(1,3,2-dioxaborinane-5,5-dimethyl)-L-phenylalanine ethyl ester 
• 1421282-25-8 ethyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2-iodo-4,5-dimethoxyphenyl)propanoate 
• 23234-41-5 2-Amino-3-(3,4-dihydroxy-phenyl)-propionic acid ethyl ester; hydrochloride 
• 59-92-7 3,4-dihydroxy-L-phenylalanine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1421282-25-8 ethyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2-iodo-4,5-dimethoxyphenyl)propanoate 
• 1421282-26-9 N-(tert-butoxycarbonyl)-3,4-(dimethoxy)-6-(iodo)-L-phenylalanine 
• 1421282-27-0 N-(tert-butoxycarbonyl)-3,4-(dimethoxy)-6-(iodo)-L-phenylalanine methyl ester 
• 1421282-28-1 N-(tert-butoxycarbonyl)-3,4-dimethoxy-6-(1,3,2-dioxaborinane-5,5-dimethyl)-L-phenylalanine ethyl ester 
• 1421282-31-6 N-(tert-butoxycarbonyl)-3,4-dimethoxy-6-(1,3,2-dioxaborinane-5,5-dimethyl)-L-phenylalanine methyl ester 
• 1421282-45-2 N-(tert-butoxycarbonyl)-3,4-di(tert-butoxycarbonyloxy)-6-fluoro-L-phenylalanine ethyl ester 
• 1421282-68-9 C₁₇H₂₄AgNO₆ 
• 853759-49-6 N-(tert-butoxycarbonyl)-3,4-di(tert-butoxycarbonyloxy)-6-fluoro-L-phenylalanine methyl ester 
• 92812-82-3 [18F]-L-3,4-dihydroxy-6-fluorophenylalanine 
• 1421282-70-3 N-(tert-butoxycarbonyl)-3,4-di(tert-butoxycarbonyloxy)-6-[¹⁸F]fluoro-L-phenylalanine methyl ester 
• 128217-76-5 2-Allyloxycarbonylamino-3-(4,5-dimethoxy-2-nitro-phenyl)-propionic acid ethyl ester 
• 128217-65-2 2-Allyloxycarbonylamino-3-(3,4-dimethoxy-phenyl)-propionic acid ethyl ester 
• 3165-57-9 2-Amino-3-(3,4-dimethoxy-phenyl)-propionic acid ethyl ester 

Relevant academic research and scientific papers

Towards a universal organocatalyst for the synthesis of enantioenriched phenylalanine derivatives by enantioselective decarboxylative protonation

Access to enantioenriched non-proteogenic phenylalanine derivatives is described using the enantioselective decarboxylative protonation reaction of amidohemimalonate esters catalysed by various cinchona-based compounds. This study compares the catalytic efficiency as well as the enantioselectivity induced by three types of common organocatalysts, namely thioureas, squaramides and bis-cinchona squaramides. One of the main outcome of this work is the observation of a significant influence of the N-protecting group of the hemimalonate on its interaction with the catalyst. This methodology carried out under mild conditions exhibits good substrate scope and functional group tolerance. A substoichiometric amount of catalyst can also be used in certain cases while affording good yields and selectivities.

Fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): Application to 6-[18F]fluoro-l-DOPA

The Ag-mediated electrophilic [18F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [ 18F]selectfluor bis(triflate) in acetone. The process gave 6-[ 18F]fluoro-l-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol-1.

Synthesis of the Chromophore of Pseudobactin, a Fluorescent Siderophore from Pseudomonas

Protected forms of dihydroxyphenylalanine (DOPA) were converted to the corresponding dihydroquinolin-2-ones 13 by nitration and reductive cyclization.Subsequent N-alkylation with α-halo-γ-aminobutyric acid derivatives provided the carbon framework 12 for the chromophore of pseudobactin.Conversion to protected forms of the fluorescent chromophore 5 was accomplished by reaction of 12 with Lawesson's reagent to produce the corresponding thioamide which was cyclized by reaction with mercuric acetate.