928128-07-8Relevant academic research and scientific papers
Synthesis and photophysical properties of a deazaflavin-bridged porphyrinatoiron(III) that mimics the interaction of a deazaflavin inhibitor with the heme-thiolate cofactor of cytochrome P450 3A4
Mueller, Michael A.,Gaplovsky, Martin,Wirz, Jakob,Woggon, Wolf-D.
, p. 2987 - 3001 (2006)
Cytochrome P450 3A4 metabolizes a majority of administered therapeutic agents in the human liver. We recently reported the synthesis of a new inhibitor, 1, whose binding to and displacement from the active site of CYP 3A4 can be conveniently followed by t
