928206-95-5

Upstream product

• 14677-99-7 3-(p-methoxyphenyl)-2-propynenitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 7605-28-9 2-(phenylsulfonyl)acetonitrile 
• 57222-08-9 2-Nitro-3-(4-methoxyphenyl)acrylnitril 

Relevant academic research and scientific papers

Metal-Free Multicomponent Reaction for Synthesis of 4,5-Disubstituted 1,2,3-(NH)-Triazoles

A metal-free domino reaction was developed for efficient synthesis of 4,5-disubstituted 1,2,3-(NH)-triazoles by sequentially coupling sulfur salts with aldehydes and sodium azide. In the presence of L-proline, olefinic sulfur salt intermediates rather than epoxides are formed in situ via the coupling of sulfur salts with aldehydes and cyclize with azide ion. This process features mild conditions, high efficiency, commercially available starting materials, and wide substrate scope. (Figure presented.).

Geminally activated nitroethenes in reactions with sodium azide. Synthesis of functionalized 1,2,3-triazoles

Reactions of geminally activated alkoxycarbonyl(acetyl, benzoyl, cyano)nitroethenes with sodium azide provided a series of functionally substituted 1,2,3-triazoles. Their structure was characterized by IR, 1H, and 13C–{1H}

Tandem Knoevenagel-[3+2] cycloaddition-elimination reactions: One-pot synthesis of 4,5-disubstituted 1,2,3-(NH)-triazoles

Sodium azide has been found to catalyse Knoevenagel condensation between aromatic aldehyde and cyano compound with active methylene hydrogens and this has led to a successful route for the one pot synthesis of 4,5-disubstituted 1,2,3-(NH)-triazoles from a

Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase

4-Aryl-5-cyano-2H-1,2,3-triazoles bearing a variety of substituting groups on 4-phenyl were synthesized. The chemicals, designed as HER2 tyrosine kinase inhibitors, were screened for bioactivity of inhibiting growth of breast cancer MDA-MB-453 cells. The