92829-72-6Relevant academic research and scientific papers
Synthesis of magnaldehydes B and e and dictyobiphenyl B by microwave-promoted cross-coupling of boronophenols
Schmidt, Bernd,Riemer, Martin
, p. 3760 - 3766 (2015/06/16)
Magnaldehydes B and E along with their 4′-methylated derivatives are naturally occurring 2,4′-biphenols that have been isolated from the Magnoliaceae. Herein, these natural products have been synthesized from a common intermediate, which was obtained by a microwave-promoted, heterogeneously catalyzed, and protecting-group-free Suzuki-Miyaura coupling reaction in an aqueous medium. These reaction conditions were also successfully applied to a one-step synthesis of the slime mold metabolite dictyobiphenyl B. A protecting-group-free Suzuki-Miyaura cross-coupling reaction of halophenols and boronophenols by using Pd/C as the catalyst and water as the solvent under microwave irradiation has been used for the synthesis of five biphenol-type natural products.
An Approach for General Synthesis of Biphenyl Neolignans by the Reaction of 1-Oxaspirodeca-6,9-diene-2,8-dione with the Grignard Reagent and Synthesis of Magnaldehyde B
Takeya, Tetsuya,Okubo, Toru,Tobinaga, Seisho
, p. 1755 - 1761 (2007/10/02)
An approach for general synthesis of biphenyl neolignans by the reactionof 1-oxaspiro-deca -6,9-diene-2,8-dione (3) (quinol-lactone) with the Grignard reagent 4 was explored.Among the biphenyl derivatives 6,8 and 9 thus obtained, 6 was transformed to magnaldehyde B (2b) in three steps.Keywords---biphenyl neolignan; synthesis; magnaldehyde B; quinol-lactone; Grignard reagent
