92829-83-9

Usage

Uses

Used in Medicinal Chemistry:
8-(benzyloxy)-1,4-dioxaspiro[4.5]decane is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique spirocyclic structure and benzyloxy group contribute to the development of novel drug candidates with potential therapeutic applications.
Used in Drug Development:
In the pharmaceutical industry, 8-(benzyloxy)-1,4-dioxaspiro[4.5]decane is utilized as a structural component in the design and synthesis of new drug molecules. Its incorporation can enhance the pharmacological properties, such as potency, selectivity, and bioavailability, of the resulting compounds.
Used in Organic Synthesis:
8-(benzyloxy)-1,4-dioxaspiro[4.5]decane serves as a valuable building block in organic synthesis, enabling the creation of diverse chemical entities. Its spirocyclic framework and benzyloxy group facilitate the formation of complex molecular architectures and the development of innovative synthetic routes.
Used in Material Science:
In the field of material science, 8-(benzyloxy)-1,4-dioxaspiro[4.5]decane is employed as a component in the design and synthesis of new materials with unique properties. Its incorporation can lead to the development of advanced materials with applications in various industries, such as electronics, coatings, and polymers.
Used in Functional Molecule Design:
8-(benzyloxy)-1,4-dioxaspiro[4.5]decane is utilized in the design of functional molecules with specific properties and applications. Its unique structure and functional group can be tailored to achieve desired characteristics, such as catalytic activity, binding affinity, or sensing capabilities, in various chemical and biological systems.

Upstream product

• 22428-87-1 4,4-ethylenedioxycyclohexan-1-ol 
• 100-39-0 benzyl bromide 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 69125-55-9 4-hydroxy-1-methoxy-1-cyclohexene 
• 78881-14-8 2-Hydroxy-1-cyclohexanon-ethylenacetal 
• 100-44-7 benzyl chloride 

Downstream Products

• 2976-80-9 4-(benzyloxy)cyclohexan-1-ol 
• 92829-91-9 Toluene-4-sulfonic acid (3E,7E)-10-(5-hydroxy-2-methyl-cyclohex-1-enyl)-4-methyl-deca-3,7-dienyl ester 
• 92829-90-8 [(3E,7E)-10-(5-Benzyloxy-2-methyl-cyclohex-1-enyl)-4-methyl-deca-3,7-dienyloxy]-tert-butyl-dimethyl-silane 
• 92829-86-2 (4-Methyl-3-methylene-4-vinyloxy-cyclohexyloxymethyl)-benzene 
• 92829-84-0 4-benzyloxy-2-dimethylaminomethyl-cyclohexanone 
• 92844-01-4 3-((3E,7E)-10-Hydroxy-7-methyl-deca-3,7-dienyl)-4-methyl-cyclohex-3-enol 
• 92829-89-5 [3-(3-Iodo-propyl)-4-methyl-cyclohex-3-enyloxymethyl]-benzene 
• 92829-88-4 Toluene-4-sulfonic acid 3-(5-benzyloxy-2-methyl-cyclohex-1-enyl)-propyl ester 
• 85221-00-7 3-(5-Benzyloxy-2-methyl-cyclohex-1-enyl)-propionaldehyde 
• 85221-01-8 3-(5-Benzyloxy-2-methyl-cyclohex-1-enyl)-propan-1-ol 
• 73658-27-2 4-Benzyloxy-1-methyl-2-methylene-cyclohexanol 
• 73658-17-0 4-Benzyloxy-2-methylene-cyclohexanone 
• 543725-01-5 3-Benzyloxy-6-hept-6-en-(E)-ylidene-cyclohex-1-enecarbaldehyde 
• 543724-95-4 [3-Bromo-4-hept-6-en-(E)-ylidene-cyclohex-2-enyloxymethyl]-benzene 

Relevant academic research and scientific papers

EMULSION WITH IMPROVED BIOABSORPTION COMPOSITION COMPRISING CATIONIC POLYESTER COPOLYMER AND HYDROPHOBIC DRUG AND METHOD FOR PREPARING THE SAME

The present invention relates to an emulsion composition with an improved bioabsorption rate containing a cationic polyester-based copolymer, and a poorly soluble drug. The emulsion composition comprises: a cationic polyester-based copolymer including a c

Hydrogen Borrowing Catalysis with Secondary Alcohols: A New Route for the Generation of β-Branched Carbonyl Compounds

A hydrogen borrowing reaction employing secondary alcohols and Ph? (Me5C6) ketones to give β-branched carbonyl products is described (21 examples). This new C-C bond forming process requires low loadings of [Cp?IrCl2]2, relatively low temperatures, and up to 2.0 equiv of the secondary alcohol. Substrate-induced diastereoselectivity was observed, and this represents the first example of a diastereoselective enolate hydrogen borrowing alkylation. By utilizing the Ph? group, the β-branched products could be straightforwardly cleaved to the corresponding esters or amides using a retro-Friedel-Crafts reaction. Finally, this protocol was applied to the synthesis of fragrance compound (±)-3-methyl-5-phenylpentanol.

COMPOUNDS USEFUL AS KINASE INHIBITORS

This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are useful as inhibitors of Bruton's tyrosine kinase (BTK).The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of Bruton's tyrosine kinase, for example cancer, lymphoma, leukemia and immunological diseases.

AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES

2-Acylindazole compounds of formula I or formula II are disclosed. These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.

Stereoelectronic Model to Explain Highly Stereoselective Reactions of Seven-Membered-Ring Oxocarbenium-Ion Intermediates

Nucleophilic attack on seven-membered-ring oxocarbenium ions is generally highly stereoselective. The preferred mode of nucleophilic attack forms the product in a conformation that minimizes transannular interactions, thus leading to different stereoselectivity as compared to that of reactions involving six-membered-ring oxocarbenium ions.

PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS

The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

Discovery of spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amines as potent NOP and opioid receptor agonists

We report the discovery of spiro[cyclohexane-pyrano[3,4-b]indole]-amines, as functional nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonists with strong efficacy in preclinical models of acute and neuropathic pain. Utilizing 4-(dimethylamino)-4-phenylcyclo-hexanone 1 and tryptophol in an oxa-Pictet-Spengler reaction led to the formation of spiroether 2, representing a novel NOP and opioid peptide receptor agonistic chemotype. This finding initially stems from the systematic derivatization of 1, which resulted in alcohols 3-5, ethers 6 and 7, amines 8-10, 22-24, and 26-28, amides 11 and 25, and urea 12, many with low nanomolar binding affinities at the NOP and mu opioid peptide (MOP) receptors.

CYCLOHEXANE ANALOGUES AS GPR119 AGONISTS

This invention relates to a series of substituted cyclohexane containing analogues which are agonists of GPR119 intended to treat metabolic diseases mediated by GPR119 including Type I & II diabetes mellitus. Diabetes mellitus is an ever-increasing threat to human health causing various complications (blindness, kidney failure, neuropathy, heart attack, stroke, etc.). Recently it was found that activation of GPR119 which is highly expressed in pancreatic beta cells causes glucose dependent insulin secretion and GLP-1 release. Many pharmaceuticals are currently developing GPR119 agonists and herein we disclose alternative GPR119 agonists. Our invention describes GPR119 agonists having structural Formula (I), pharmaceutically acceptable salt or solvate of Formula (I), isomer or prodrug of Formula (I), and combination therapy of Formula (I) with other anti-diabetic drugs like DPP-IV inhibitors and/or insulin sensitizers.

PENTYLENETETRAZOLE DERIVATIVES

Provided are compounds having formula I: ( l ) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as disclosed herein, or a pharmaceutically

HERBICIDALLY ACTIVE 2-(SUBSTITUTED-PHENYL)-CYCLOPENTANE-1,3-DIONE DERIVATIVES

Compounds of formula (I) are suitable for use as herbicides: wherein R is methyl, ethyl, vinyl, ethynyl or cyclopropyl, R1 is hydrogen, C1-C6alkyl, C1-C6haloalkyl, C3-C7cycloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, vinyl, propenyl, ethynyl, propynyl, halogen, or optionally substituted phenyl, R2 is methyl, ethyl, vinyl, ethynyl or methoxy, R3 and R4 are hydrogen or together form a double bond, A is C3-C7cycloalkyl which is unsubstituted or substituted once or twice by C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6alkylcarbonyloxy, C2-C6alkenyl, =0 or =N-R10, or A is cyclohexyl substituted once, at the 4-position, by one (C3-C6cycloalkyl)methoxy, C3-C6cycloalkyloxy, C2-C5alkenyl-CH2-oxy, or benzyloxy substituent, or A is decahydro-1-naphthyl or decahydro-2-naphthyl, or A is optionally substituted phenyl, and G is hydrogen or an agriculturally acceptable metal, sulfonium, ammonium or a latentiating group.