92855-06-6Relevant academic research and scientific papers
Synthesis and antifungal activities of natural and synthetic biflavonoids
Sagrera, Gabriel,Bertucci, Ana,Vazquez, Alvaro,Seoane, Gustavo
, p. 3060 - 3073 (2011/06/27)
The synthesis of some natural and synthetic biflavonoids was performed in good overall yields starting from readily available materials via high yielding aldol and Ullmann condensations. Some of these compounds, especially bichalcones, display an interesting activity against fungi, higher than that of the corresponding monomers.
Reactions of Aryl Ketones and Coumarins with Iodine(III) Tris(trifluoroacetate)
Fukuyama, Norihiro,Nishino, Hiroshi,Kurosawa, Kazu
, p. 4363 - 4368 (2007/10/02)
The reaction of acetophenones with iodine(III) tris(trifluoroacetate) yields 3'- and/or 2-iodo derivatives, depending upon the substituent on the aromatic ring and the reaction conditions.The reaction was examinedby changing the molar ratio of acetophenone versus the reagent, reaction temperature, and solvent.In similar reactions flavanones and coumarins gave iodo derivatives in which iodine is incorporated at various positions orientated by the oxygen functions. 1,2-Diphenylethanone yields 2-hydroxy-2-(2-iodophenyl)-1-phenylethanone and 1-(2-iodophenyl)-2-phenylethanedione.The reactions of other aromatic ketones such as 9-xanthenone, 9-fluorenone, and anthrone also give iodo derivatives in moderate to good yields.The mechanisms for the iodination at the α-carbon to the carbonyl group have been discussed.
