3034-08-0

Basic information

• Product Name: 4'-METHOXYFLAVANONE
• Synonyms: 4'-METHOXYFLAVANONE;METHOXYFLAVANONE, 4'-;METHOXYFLAVANONE, 4'-(P);2-(4-Methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one;2,3-Dihydro-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;2-(4-methoxyphenyl)-2,3-dihydrochromen-4-one;(S)-4'-Methoxyflavanone;(2S)-2,3-Dihydro-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
• CAS NO: 3034-08-0
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.28
• Product Categories: Flavanones
• Mol File: 3034-08-0.mol
• Article Data: 101

Chemical Properties

• Melting Point: 92-94°C
• Boiling Point: 421.8°Cat760mmHg
• Flash Point: 200.7°C
• Appearance: /
• Density: 1.199g/cm³
• Vapor Pressure: 2.53E-07mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 4'-METHOXYFLAVANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-METHOXYFLAVANONE(3034-08-0)
• EPA Substance Registry System: 4'-METHOXYFLAVANONE(3034-08-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 3034-08-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H14O3/c1-18-12-8-6-11(7-9-12)16-10-14(17)13-4-2-3-5-15(13)19-16/h2-9,16H,10H2,1H3/t16-/m0/s1

Upstream product

• 108837-17-8 2-hydroxy-4-methoxy-trans(?)-chalcone 
• 61854-49-7 4'-methoxyflavanone hydrazone 
• 118-93-4 o-hydroxyacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 1469-94-9 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione 
• 32865-61-5 2-iodophenyl acetate 
• 5162-64-1 (+)-(2S,4S)-4'-methoxyflavan-4-ol 
• 3034-08-0 2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one 
• 3327-24-0 1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one 
• 5162-64-1 2-(4-methoxyphenyl)chroman-4-ol 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 936182-86-4 tert-butyl 3-(2-hydroxyphenyl)-3-oxopropanoate 
• 936183-85-6 tert-butyl (E)-2-(2-hydroxyphenylcarbonyl)-3-(4-methoxyphenyl)prop-2-enoate 
• 56202-01-8 1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-propan-1-one 

Downstream Products

• 4143-74-2 4'-methoxyflavone 
• 6889-78-7 4'-(methoxy)-3-hydroxyflavone 
• 150073-64-6 3-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-2-(4-methoxy-phenyl)-chroman-4-one 
• 150073-63-5 2-(4-Methoxy-phenyl)-3-[1-phenyl-meth-(E)-ylidene]-chroman-4-one 
• 132361-71-8 3-(4-methoxybenzylidene)-4'-methoxyflavanone 
• 92855-06-6 3'-iodo-4'-methoxyflavanone 
• 1621-58-5 3-(4-methoxyphenyl)-4H-chromen-4-one 
• 34000-27-6 (2E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one 
• 34000-29-8 [E]-3-(p-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 71993-33-4 3-chloro-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 100-09-4 4-methoxybenzoic acid 
• 95731-61-6 r-3-acetoxy-t-2-(4-methoxyphenyl)-4-chromanone 
• 71993-29-8 3,3-dichloro-2-(4-methoxyphenyl)-4-chromanone 
• 73910-85-7 3-bromo-2-(4-methoxyphenyl)-4H-chromen-4-one 

Relevant articles and documents

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Synthesis, stereochemistry and antimicrobial activity of some novel flavanone-hydrazono-thiazolidin-4-ones from flavanones

The synthesis of four novel compounds, (i) E-2-{[2-(4-methoxyphenyl)chroman-E-4-ylidene]hydrazono}thiazolidin-4-one (4a), (ii) E-2-{[2-(4-methoxyphenyl)chroman-Z-4-ylidene]hydrazono}thiazolidin-4-one (5a), (iii) E-2-{[2-(phenyl)chroman-E-4-ylidene]hydrazo

B regioselective and chemoselective biotransformation of 2′-hydroxychalcone derivatives by marine-derived fungi

Eight fungal strains (Penicillium raistrickii CBMAI 931, Cladosporium sp. CBMAI 1237, Aspergillus sydowii CBMAI 935, Penicillium oxalicum CBMAI 1996, Penicillium citrinum CBMAI 1186, Mucor racemosus CBMAI 847, Westerdykella sp. CBMAI 1679, and Aspergillus sclerotiorum CBMAI 849) mediated the biotransformation of the 2′-hydroxychalcone 1a. The main products obtained were from hydrogenation, hydroxylation, and cyclization reactions. Penicillium raistrickii CBMAI 931 catalyzed the chemoselective reduction of 1a to produce 2′-hydroxydihydrochalcone 2a (72%) in 7 days of incubation in phosphate buffer (pH 7). Aspergillus sydowii CBMAI 935 promoted the hydroxylation of 1a to yield 2′,4-dihydroxy-dihydrochalcone 5a (c = 42%) in 7 days of incubation in phosphate buffer (pH 8). The reaction using P. citrinum CBMAI 1186 and M. racemosus CBMAI 847 presented main cyclization products in phosphate buffer (pH 8), but the reactions with these fungi did not present enantioselectivity. Marine-derived fungi were effective and versatile biocatalysts for biotransformation of the 2′-hydroxychalcones yielding different products according to the conditions and microorganism used.

Glycolytic inhibition and antidiabetic activity on synthesized flavanone scaffolds with computer aided drug designing tools

Background: Diabetes mellitus is a challengeable metabolic disorder that leads to a group of complications when the HbA1c level is not maintained. Most of the existing drugs avail-able in the market in long-term use may lead to serious adverse effects. He

Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalconesviapalladium(ii)-catalyzed oxidative cyclization

Divergent and versatile synthetic routes to flavones and flavanonesviaefficient Pd(ii) catalysis are disclosed. These Pd(ii) catalyses expediently provide a variety of flavones and flavanones from 2′-hydroxydihydrochalcones as common intermediates, depending on oxidants and additives,viadiscriminate oxidative cyclization sequences involving dehydrogenation, respectively, in a highly atom-economic manner.