928656-36-4Relevant articles and documents
The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-α and IKK-β kinases
Christopher, John A.,Avitabile, Barbara G.,Bamborough, Paul,Champigny, Aurelie C.,Cutler, Geoffrey J.,Dyos, Susan L.,Grace, Ken G.,Kerns, Jeffrey K.,Kitson, Jeremy D.,Mellor, Geoffrey W.,Morey, James V.,Morse, Mary A.,O'Malley, Carolyn F.,Patel, Champa B.,Probst, Nicholas,Rumsey, William,Smith, Clive A.,Wilson, Michael J.
, p. 3972 - 3977 (2008/02/09)
A potent and selective series of 2-amino-3,5-diarylbenzamide inhibitors of IKK-α and IKK-β is described. The most potent compounds are 8h, 8r and 8v, with IKK-β inhibitory potencies of pIC50 7.0, 6.8 and 6.8, respectively. The series has excell
