928783-85-1

Basic information

• Product Name: 3-Bromo-5-Chlorobenzotrifluoride
• Synonyms: 3-Bromo-5-Chlorobenzotrifluoride;1-Bromo-3-chloro-5-(trifluoromethyl)benzene;3-Chloro-5-trifluoromethylbromobenzene;1-Bromo-3-chloro-5-(trifluoromethyl)benzene, 3-Bromo-5-chloro-alpha,alpha,alpha-trifluorotoluene;3-BroMo-5-chlorobenzotrifluoride, 97%+;3-chloro-5-bromo trifluoromethylbenzene
• CAS NO: 928783-85-1
• Molecular Formula: C₇H₃BrClF₃
• Molecular Weight: 259.4509296
• Mol File: 928783-85-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 182℃
• Flash Point: 64℃
• Appearance: /
• Density: 1.717
• Vapor Pressure: 1.15mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-Bromo-5-Chlorobenzotrifluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-Chlorobenzotrifluoride(928783-85-1)
• EPA Substance Registry System: 3-Bromo-5-Chlorobenzotrifluoride(928783-85-1)

Safety Data

• Hazardous Substances Data: 928783-85-1(Hazardous Substances Data)

Usage

Chemical Properties

light yellow liquid

InChI:InChI=1/C7H3BrClF3/c8-5-1-4(7(10,11)12)2-6(9)3-5/h1-3H

Upstream product

• 445-02-3 4-bromo-2-trifluoromethyl-aniline 
• 870703-71-2 4-bromo-2-chloro-6-(trifluoromethyl)aniline 
• 88-17-5 2-(trifluoromethyl)benzenamine 

Downstream Products

• 346729-48-4 1-(3-chloro-5-(trifluoromethyl)phenyl)piperazine 
• 1125812-58-9 1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one 
• 1299483-09-2 (2E)-3-[4-(cyclopropylcarbamoyl)-3-trifluoromethylphenyl]acrylic acid 
• 1299483-02-5 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethanamine 
• 1198180-50-5 ({1-[3-chloro-5-(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid 
• 1198181-75-7 1-[3-chloro-5-(trifluoromethyl)phenyl]pyrrolidin-3-ol 

Relevant articles and documents

Method for synthesizing 3 -chloro -5 -trifluoromethyltrifluoroacetophenone

The invention discloses a method for synthesizing 3 -chloro -5 -trifluoromethyltrifluoroacetophenone, which comprises the following steps: firstly bromination and rechlorination of o-aminotrifluorotoluene to obtain 4 - bromo -2 - chloro -6 - trifluoromethylaniline. 4 - Bromo -2 - chloro -6 - trifluoromethylaniline was subjected to diazotization followed by treatment with hypophosphorous acid or ethanol to give the deamination compound 1 - bromo -3 - chloro -5 - (trifluoromethyl) benzene. 1 - Bromo -3 - chloro -5 - (trifluoromethyl) benzene was made into Grignard reagent with magnesium chips and reacted with the acylating agent to give 3 - chloro -5 - trifluoromethyltrifluoroacetophenone. The starting material ortho-aminotrifluorotoluene used in the route is a common chemical with cheap price, and the obtained product is high in purity and yield, relatively small in environmental pollution and expected to be used for large-scale industrial production.