870703-71-2

Usage

Uses

Used in Organic Synthesis:
4-BROMO-2-CHLORO-6-(TRIFLUOROMETHYL)ANI& is used as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows for further functionalization and modification, making it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-BROMO-2-CHLORO-6-(TRIFLUOROMETHYL)ANI& is used as a starting material for the development of new drugs. Its unique properties and reactivity make it a promising candidate for the synthesis of novel pharmaceutical agents with potential therapeutic applications.
Used in Agrochemicals:
4-BROMO-2-CHLORO-6-(TRIFLUOROMETHYL)ANI& is also utilized in the agrochemical industry for the development of new pesticides and herbicides. Its halogenated nature and chemical reactivity contribute to the creation of effective and targeted agrochemical products.
Used in the Synthesis of Functional Materials:
4-BROMO-2-CHLORO-6-(TRIFLUOROMETHYL)ANI& is employed as a building block for the synthesis of various functional materials, such as polymers, dyes, and sensors. Its unique structure and reactivity enable the development of materials with specific properties and applications in different industries.

InChI:InChI=1/C7H4BrClF3N/c8-3-1-4(7(10,11)12)6(13)5(9)2-3/h1-2H,13H2

Upstream product

• 445-02-3 4-bromo-2-trifluoromethyl-aniline 
• 887144-94-7 Togni's reagent II 
• 38762-41-3 2-chloro-4-bromoaniline 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 433-94-3 2-chloro-6-(trifluoromethyl)benzenamine 

Downstream Products

• 1009344-66-4 N-(4-bromo-2-chloro-6-(trifluoromethyl)phenyl)-3,3-dimethylbutanamide 
• 1009344-69-7 N-(4-Bromo-2-chloro-6-trifluoromethyl-phenyl)-3-cyclopentyl-propionamide 
• 1326311-05-0 5-bromo-1-chloro-2-nitro-3-(trifluoromethyl)benzene 
• 1326311-06-1 5-bromo-N-methyl-2-nitro-3-(trifluoromethyl)aniline 
• 1326311-07-2 [5-(dimethylamino)-2-nitro-3-(trifluoromethyl)phenyl]methylamine 
• 1326311-08-3 [2-amino-5-(dimethylamino)-3-(trifluoromethyl)phenyl]methylamine 
• 928783-85-1 1-bromo-3-chloro-5-(trifluoromethyl)benzene 

Relevant academic research and scientific papers

Method for synthesizing 3 -chloro -5 -trifluoromethyltrifluoroacetophenone

The invention discloses a method for synthesizing 3 -chloro -5 -trifluoromethyltrifluoroacetophenone, which comprises the following steps: firstly bromination and rechlorination of o-aminotrifluorotoluene to obtain 4 - bromo -2 - chloro -6 - trifluoromethylaniline. 4 - Bromo -2 - chloro -6 - trifluoromethylaniline was subjected to diazotization followed by treatment with hypophosphorous acid or ethanol to give the deamination compound 1 - bromo -3 - chloro -5 - (trifluoromethyl) benzene. 1 - Bromo -3 - chloro -5 - (trifluoromethyl) benzene was made into Grignard reagent with magnesium chips and reacted with the acylating agent to give 3 - chloro -5 - trifluoromethyltrifluoroacetophenone. The starting material ortho-aminotrifluorotoluene used in the route is a common chemical with cheap price, and the obtained product is high in purity and yield, relatively small in environmental pollution and expected to be used for large-scale industrial production.

Transition metal-free direct C–H trifluoromethyltion of (hetero)arenes with Togni's reagent

A new transition-metal-free direct C–H trifluoromethylation reaction of (hetero)arenes with Togni's reagent was developed. This transformation proceeded smoothly under mild conditions and exhibited good tolerance of many synthetically relevant functional groups. It provided an alternative approach for the synthesis of trifluoromethylated (hetero)arenes.

Nickel-Catalyzed Direct C-H Trifluoromethylation of Free Anilines with Togni's Reagent

An efficient nickel-catalyzed C-H trifluoromethylation for the synthesis of trifluoromethylated free anilines using Togni's reagent has been developed. This approach exhibits a good functional group tolerance, good regioselectivity, and chemoselectivity under mild conditions. The newly developed economical one-step method is a better alternative to synthesize trifluoromethylated free anilines.

Preparation method of trifluoromethylamine

The invention relates to a preparation method of trifluoromethylamine. The method includes the following steps that aromatic amine shown in the formula (1) and a trifluoromethyl reagent shown in the formula (2) react in a solvent under the condition that an alkali and/or nickel compound exists, and the trifluoromethylamine compound shown in the formula (3) is generated. According to the preparation method of trifluoromethylamine, aromatic amine and 1-trifluoromethyl-1,2-iodobenzoyl-3(H)-ketone serve as raw materials and react under the condition that the alkali and/or nickel compound exists through the amino positioning effect on aromatic nucleus. The synthesis steps of the method are simple, the cost of the raw materials is low, the production cost of trifluoromethylamine can be greatly reduced, and large-scale industrialized production is promoted.

BENZIMIDAZOLE ANTIVIRAL AGENTS

Provided are compounds of Formula (I) and (II) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).

Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators

This invention provides a compound of formula IA where X═O or S; Y is O or S; q=1 or 0; and other substituents are defined herein. Such compounds can affect the opening of, or otherwise modulate, voltage-gated potassium channels. They are potentially usef