870703-71-2

Basic information

• Product Name: 4-BROMO-2-CHLORO-6-(TRIFLUOROMETHYL)ANI&
• Synonyms: 2-Amino-5-bromo-3-chlorobenzotrifluoride; 4-Bromo-2-chloro-6-(trifluoromethyl)benzenamine; 4-Bromo-6-chloro-α,α,α-trifluoro-o-toluidine; Benzenamine, 4-bromo-2-chloro-6-(trifluoromethyl)-; ZR BG DE FXFFF [WLN]
• CAS NO: 870703-71-2
• Molecular Formula: C₇H₄BrClF₃N
• Molecular Weight: 274.467
• Product Categories: Amines;C2 to C6;Nitrogen Compounds;Building Blocks;C6;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 870703-71-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 220.3°C at 760 mmHg
• Flash Point: 87°C
• Appearance: /
• Density: 1.769 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.114mmHg at 25°C
• Refractive Index: n20/D 1.545(lit.)
• CAS DataBase Reference: 4-BROMO-2-CHLORO-6-(TRIFLUOROMETHYL)ANI&(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-CHLORO-6-(TRIFLUOROMETHYL)ANI&(870703-71-2)
• EPA Substance Registry System: 4-BROMO-2-CHLORO-6-(TRIFLUOROMETHYL)ANI&(870703-71-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 870703-71-2(Hazardous Substances Data)

Usage

General Description

4-BROMO-2-CHLORO-6-(TRIFLUOROMETHYL)ANI& is a chemical compound with the molecular formula C7H3BrClF3. It is a halogenated aromatic compound that has a bromine atom, a chlorine atom, and a trifluoromethyl group attached to a benzene ring. 4-BROMO-2-CHLORO-6-(TRIFLUOROMETHYL)ANI& is commonly used in organic synthesis and pharmaceutical research. It is also known for its potential use in agrochemicals and as a building block for the synthesis of various functional materials. The unique combination of halogen substituents makes 4-BROMO-2-CHLORO-6-(TRIFLUOROMETHYL)ANI& an important and versatile compound in the field of chemistry.

InChI:InChI=1/C7H4BrClF3N/c8-3-1-4(7(10,11)12)6(13)5(9)2-3/h1-2H,13H2

Upstream product

• 433-94-3 2-chloro-6-(trifluoromethyl)benzenamine 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 887144-94-7 Togni's reagent II 
• 38762-41-3 2-chloro-4-bromoaniline 
• 445-02-3 4-bromo-2-trifluoromethyl-aniline 

Downstream Products

• 1009344-66-4 N-(4-bromo-2-chloro-6-(trifluoromethyl)phenyl)-3,3-dimethylbutanamide 
• 1009344-69-7 N-(4-Bromo-2-chloro-6-trifluoromethyl-phenyl)-3-cyclopentyl-propionamide 
• 1326311-05-0 5-bromo-1-chloro-2-nitro-3-(trifluoromethyl)benzene 
• 1326311-06-1 5-bromo-N-methyl-2-nitro-3-(trifluoromethyl)aniline 
• 1326311-07-2 [5-(dimethylamino)-2-nitro-3-(trifluoromethyl)phenyl]methylamine 
• 1326311-08-3 [2-amino-5-(dimethylamino)-3-(trifluoromethyl)phenyl]methylamine 
• 928783-85-1 1-bromo-3-chloro-5-(trifluoromethyl)benzene 

Relevant articles and documents

Method for synthesizing 3 -chloro -5 -trifluoromethyltrifluoroacetophenone

The invention discloses a method for synthesizing 3 -chloro -5 -trifluoromethyltrifluoroacetophenone, which comprises the following steps: firstly bromination and rechlorination of o-aminotrifluorotoluene to obtain 4 - bromo -2 - chloro -6 - trifluoromethylaniline. 4 - Bromo -2 - chloro -6 - trifluoromethylaniline was subjected to diazotization followed by treatment with hypophosphorous acid or ethanol to give the deamination compound 1 - bromo -3 - chloro -5 - (trifluoromethyl) benzene. 1 - Bromo -3 - chloro -5 - (trifluoromethyl) benzene was made into Grignard reagent with magnesium chips and reacted with the acylating agent to give 3 - chloro -5 - trifluoromethyltrifluoroacetophenone. The starting material ortho-aminotrifluorotoluene used in the route is a common chemical with cheap price, and the obtained product is high in purity and yield, relatively small in environmental pollution and expected to be used for large-scale industrial production.

Nickel-Catalyzed Direct C-H Trifluoromethylation of Free Anilines with Togni's Reagent

An efficient nickel-catalyzed C-H trifluoromethylation for the synthesis of trifluoromethylated free anilines using Togni's reagent has been developed. This approach exhibits a good functional group tolerance, good regioselectivity, and chemoselectivity under mild conditions. The newly developed economical one-step method is a better alternative to synthesize trifluoromethylated free anilines.

BENZIMIDAZOLE ANTIVIRAL AGENTS

Provided are compounds of Formula (I) and (II) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).