1125812-58-9

Usage

Uses

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone is used as an organic synthesis intermediate for the production of various chemicals and compounds. Its application reason is its unique chemical structure, which allows for further reactions and modifications to create a wide range of products.
Used in Pharmaceutical Industry:
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone is used as a pharmaceutical intermediate for the development of new drugs. Its application reason is its potential to be incorporated into the molecular structure of pharmaceutical compounds, which can then be tested for their therapeutic effects and safety.
Used in Chemical Research and Development:
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone is used as a research compound in the laboratory for studying its chemical properties and potential applications. Its application reason is to gain a deeper understanding of its reactivity, stability, and interactions with other compounds, which can lead to the discovery of new chemical processes and products.
Used in Chemical Production Process:
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone is used in the chemical production process to synthesize various chemicals and materials. Its application reason is its versatility as a starting material, which can be transformed into a range of products through different chemical reactions and processes.

Synthesis

Cool the solution containing compound III (74.4g, 0.255mol containing compound III) to -100, and add 120g of sulfuric acid with a mass fraction of 92.5% to the above system while keeping the temperature below 0. After acidification, continue to react and keep for 1.5h, and then add 126.7g of 33% sodium nitrite aqueous solution (containing diazotizing reagent sodium nitrite 0.612mol) into the system uniformly within 2h, and keep the temperature at 0 The following reaction is carried out for 2 hours, and the system is heated to room temperature after full reaction, 111.1 g of 50% hypophosphorous acid and 0.67 g of cuprous oxide are added, and the reaction is stirred for 2 hours while keeping temperature. After the reaction is over, stand to separate the layers, and wash the organic layer with a 5% sodium bicarbonate aqueous solution, dry with anhydrous magnesium sulfate, and rectify to obtain a clear and transparent oily liquid 1-[3-chloro-5-(trifluoromethyl) (Yl)phenyl]-2,2,2-trifluoroethanone 66.9, content 99.5%, yield 87.2%.

Upstream product

• 431-47-0 trifluoroacetic acid-methyl ester 
• 1189352-83-7 1-chloro-3-iodo-5-(trifluoromethyl)benzene 
• 383-63-1 ethyl trifluoroacetate, 
• 928783-85-1 1-bromo-3-chloro-5-(trifluoromethyl)benzene 
• 53985-49-2 3-chloro-5-(trifluoromethyl)benzoic acid 
• 886496-83-9 3-chloro-5-trifluoromethylbenzoic acid chloride 
• 1214361-12-2 methyl 3-chloro-5-(trifluoromethyl)benzoate 
• 445-02-3 4-bromo-2-trifluoromethyl-aniline 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 354-32-5 trifluoracetyl chloride 
• 1233967-39-9 C₁₄H₁₃F₆NO₂ 
• 25617-34-9 2,2-dimethyl-N-(4-trifluoromethylphenyl)propanamide 
• 455-14-1 4-trifluoromethylphenylamine 
• 489429-73-4 1-(2-amino-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone 

Downstream Products

• 1125812-62-5 methyl 4-[3-[3-chloro-5-(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-1-naphthalenecarboxylate 
• 1124287-50-8 (E)-4-[3-[3-chloro-5-(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide 
• 1124268-39-8 (Z)-4-[3-[3-chloro-5-(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide 
• 1125812-56-7 4-[3-[3-chloro-5-(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide 
• 1299483-02-5 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethanamine 
• 1299483-09-2 (2E)-3-[4-(cyclopropylcarbamoyl)-3-trifluoromethylphenyl]acrylic acid 
• 1093861-60-9 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide 

Relevant academic research and scientific papers

Method for synthesizing 3 -chloro -5 -trifluoromethyltrifluoroacetophenone

The invention discloses a method for synthesizing 3 -chloro -5 -trifluoromethyltrifluoroacetophenone, which comprises the following steps: firstly bromination and rechlorination of o-aminotrifluorotoluene to obtain 4 - bromo -2 - chloro -6 - trifluoromethylaniline. 4 - Bromo -2 - chloro -6 - trifluoromethylaniline was subjected to diazotization followed by treatment with hypophosphorous acid or ethanol to give the deamination compound 1 - bromo -3 - chloro -5 - (trifluoromethyl) benzene. 1 - Bromo -3 - chloro -5 - (trifluoromethyl) benzene was made into Grignard reagent with magnesium chips and reacted with the acylating agent to give 3 - chloro -5 - trifluoromethyltrifluoroacetophenone. The starting material ortho-aminotrifluorotoluene used in the route is a common chemical with cheap price, and the obtained product is high in purity and yield, relatively small in environmental pollution and expected to be used for large-scale industrial production.

Preparation method of trifluoroacetophenone derivative

The invention relates to the field of organic synthesis, in particular to a preparation method of a trifluoroacetophenone derivative. Substituted aniline is used as a raw material, and preparation of the trifluoroacetophenone derivative is completed through three steps including diazotization reaction, coupling reaction and hydrolysis reaction. The preparation method has the advantages of simple process, high yield and less three wastes generated by the whole reaction, and is suitable for large-scale industrial production.

Preparation method of 1-[3-chloro-5-(trifluoromethyl) phenyl]-2, 2, 2-trifluoroethanone and derivatives thereof

The invention relates to the field of synthesis of drug intermediates, in particular to a preparation method of 1-[3-chloro-5-(trifluoromethyl) phenyl]-2, 2, 2-trifluoroethanone and derivatives thereof, and the method comprises the following steps: synthe

HYDRAZIDE COMPOUND AND ITS APPLICATION FOR CONTROLLING HARMFUL ARTHROPOD

PROBLEM TO BE SOLVED: To provide a composition having excellent controlling effect on harmful arthropod. SOLUTION: There is provided a hydrazide compound represented by the formula (1), where X1 and X2 are the same or different and represent a halogen atom, R1 represents hydrogen or a methyl group, R2 represents a C1 to C12 chain hydrocarbon group which may have a group selected from a group E1, a C3 to C12 cyclic hydrocarbon group which may have a group selected from a group E2, a 5 to 6-membered hetero cyclic group which may have a group selected from the group E2, an OR3 group, a N(R4)R5 group or a hydrogen atom. The compound has excellent controlling effect on harmful arthropod. COPYRIGHT: (C)2015,JPO&INPIT

Haloalkyl-substituted amides as insecticides and acaricides

The present invention relates to halogen-substituted amide derivatives of the general formula (I)in which R1 to R6, Q1 to Q8, A, V, W, X, Y, n and m are each defined as described in the descriptionand to a process for preparation thereof and to the use th

METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES

Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR11 or NR12 R13, and R11, R12 and R13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.