929095-72-7Relevant academic research and scientific papers
Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding
Emmitte, Kyle A.,Adjebang, George M.,Andrews, C. Webb,Alberti, Jennifer G. Badiang,Bambal, Ramesh,Chamberlain, Stanley D.,Davis-Ward, Ronda G.,Dickson, Hamilton D.,Hassler, Daniel F.,Hornberger, Keith R.,Jackson, Jeffrey R.,Kuntz, Kevin W.,Lansing, Timothy J.,Mook Jr., Robert A.,Nailor, Kristen E.,Pobanz, Mark A.,Smith, Stephon C.,Sung, Chiu-Mei,Cheung, Mui
scheme or table, p. 1694 - 1697 (2009/12/03)
A series of thiophene PLK1 inhibitors was optimized for increased solubility and reduced protein binding through the appendage of basic amine functionality. Interesting selectivity between PLK1 and PLK3 was also obtained through these modifications.
Regioselective synthesis of benzimidazole thiophene inhibitors of polo-like kinase 1
Hornberger, Keith R.,Badiang, Jennifer G.,Salovich, James M.,Kuntz, Kevin W.,Emmitte, Kyle A.,Cheung, Mui
scheme or table, p. 6348 - 6351 (2009/04/07)
A regioselective synthesis of novel 1-(2-thienyl)-benzimidazole inhibitors of polo-like kinase 1 is described. Amination of substituted 2-iodo or -bromo nitrobenzenes with a 2-aminothiophene derivative catalyzed by Pd2dba3 and XANTPH
BENZIMIDAZOLE THIOPHENE COMPOUNDS
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Page/Page column 77-78, (2010/11/26)
The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES
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Page/Page column 69, (2010/11/26)
The present invention provides a process for preparing benzimidazole thiophene compounds of formula I. Intermediates used in the process are also claimed.
