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Usage

Uses

Used in Pharmaceutical Industry:
(3S,4S,6R)-5-2-Oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl-N-(prop-2-en-1-yl)pentanamide is used as a potential candidate for pharmaceutical applications due to its unique molecular structure and functional groups. Its specific application reason is yet to be determined and would require further research and testing to fully understand its properties and potential uses.
Used in Organic Synthesis:
In the field of organic synthesis, (3S,4S,6R)-5-2-Oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl-N-(prop-2-en-1-yl)pentanamide is used as a reagent for the synthesis of other complex organic compounds. Its unique structure and functional groups make it a valuable building block for creating novel molecules with potential applications in various industries.

Upstream product

• 107-11-9 1-amino-2-propene 
• 58-85-5 biotin 

Relevant academic research and scientific papers

Genetic Incorporation of Olefin Cross-Metathesis Reaction Tags for Protein Modification

Olefin cross-metathesis (CM) is a viable reaction for the modification of alkene-containing proteins. Although allyl sulfide or selenide side-chain motifs in proteins can critically enhance the rate of CM reactions, no efficient method for their site-selective genetic incorporation into proteins has been reported to date. Here, through the systematic evaluation of olefin-bearing unnatural amino acids for their metabolic incorporation, we have discovered S-allylhomocysteine (Ahc) as a genetically encodable Met analogue that is not only processed by translational cellular machinery but also a privileged CM substrate residue in proteins. In this way, Ahc was used for efficient Met codon reassignment in a Met-auxotrophic strain of E. coli (B834 (DE3)) as well as metabolic labeling of protein in human cells and was reactive toward CM in several representative proteins. This expands the use of CM in the toolkit for "tag-and-modify" functionalization of proteins.