651293-82-2

Usage

Uses

Used in Pharmaceutical Industry:
7,13-Bis-O-(triethylsilyl)-10-deacetyl-10-oxo Baccatin III is used as a key intermediate in the preparation of taxane derivatives for their antitumoral and antineoplastic properties. Taxanes are known for their ability to stabilize microtubules, disrupt mitosis, and induce cell cycle arrest, leading to the inhibition of tumor growth and the prevention of metastasis. 7,13-Bis-O-(triethylsilyl)-10-deacetyl-10-oxo Baccatin III plays a crucial role in the development of novel taxane-based anticancer drugs, which can potentially offer improved efficacy, reduced side effects, and overcome drug resistance in cancer treatment.

Upstream product

• 79271-56-0 triethylsilyl trifluoromethyl sulfonate 
• 92950-45-3 10-dehydro 10-deacetyl 7-epibaccatin V 
• 32981-86-5 10-deacetylbaccatin III 

Downstream Products

• 943239-53-0 C₄₁H₆₆O₁₀Si₂ 
• 1067643-34-8 C₃₄H₄₂O₁₁ 
• 1029600-32-5 SY₅₈₆-170.1 
• 1269040-35-8 C₄₃H₆₁NO₁₅ 
• 1447950-53-9 C₄₈H₆₇NO₁₅ 
• 1269040-80-3 SY₆₃₄-70AP₁ 
• 1269040-79-0 C₄₅H₆₁NO₁₆ 
• 1269040-78-9 SY₆₃₄-69P₁ 
• 1269040-76-7 SY₆₃₄-58P₂ 
• 1269040-73-4 SY₆₃₄-58P₁ 
• 1269040-70-1 SY₆₃₄-55P₁c 
• 1269040-71-2 SY₆₃₄-55P₂c 
• 1051405-47-0 C₄₆H₆₃NO₁₅ 
• 1051405-95-8 C₃₄H₄₂O₁₁ 

Relevant academic research and scientific papers

TAXANE AND ABEO-TAXANE ANALOGS

The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes and methods of treating cancer with the abeo-taxanes.

TAXANE ANALOGUES, THEIR USE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION

The present invention relates to novel taxane analogues, processes of making the novel taxane analogues, compositions containing the novel taxane analogues, and their use in treating cancer and neurodegenerative disorders. In some embodiments, the taxane analogues are represented by the generic structure of formula (I) : wherein R1, R2,R3 and A are defined herein; and esters especially pro-drugs thereof wherein one or more of the hydroxy! groups is esterified to form an in-vivo hydrolysable ester group; or pharmaceutically acceptable salts thereof.

BIOLOGICALLY ACTIVE TAXANE ANALOGS AND METHODS OF TREATMENT BY ORAL ADMINISTRATION

The present invention relates to a novel chemical compound of formula S-(I) for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.

TAXANE ANALOGS FOR THE TREATMENT OF BRAIN CANCER

Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a s

PROCESSES FOR TAXANE DERIVATIVES AND INTERMEDIATES USEFUL THEREIN

The application provides a process for the preparation of taxane derivatives and intermediates useful in such processes.

The Reductive Fragmentation of 7-Hydroxy-9,10-dioxotaxoids

The retro-aldol reductive fragmentation of different structural types of 7-hydroxy-9,10-dioxotaxoids was investigated, showing that the reaction is typical of taxanes and requires cerium(III) promotion with NaBH4 in protic medium and alkylboron (aluminium) hydrides in aprotic solvents. The resulting 7,8-seco-taxanes are key intermediates for the synthesis of a novel class of anticancer taxanes endowed with a unique pattern of in vivo biological activity. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.