929520-00-3Relevant articles and documents
Highly constrained bicyclic VLA-4 antagonists
Chang, Linda L.,Truong, Quang,Doss, George A.,MacCoss, Malcolm,Lyons, Kathryn,McCauley, Ermengilda,Mumford, Richard,Forrest, Gail,Vincent, Stella,Schmidt, John A.,Hagmann, William K.
, p. 597 - 601 (2008/02/05)
VLA-4 is implicated in several inflammatory and autoimmune disease states. A series of cyclic β-amino acids (β-aa) was studied as VLA-4 antagonists. Binding affinity was highly dependent on the dihedral angle (φ{symbol}) between the amino and the carboxyl
