929556-48-9

Upstream product

• 85064-61-5 2-(tetrahydro-2H-pyran-4-yl)acetic acid 
• 100-51-6 benzyl alcohol 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 130312-00-4 ethyl tetrahydro-4H-pyran-4-ylideneacetate 
• 100-39-0 benzyl bromide 

Downstream Products

• 1420039-50-4 benzyl 2-oxo-2-(tetrahydro-2H-pyran-4-yl)acetate 
• 1420039-52-6 dibenzyl 2-hydroxy-2,3-bis(tetrahydro-2H-pyran-4-yl)succinate 
• 1420039-48-0 benzyl 2-hydroxy-2-(tetrahydro-2H-pyran-4-yl)acetate 

Relevant academic research and scientific papers

NDM INHIBITOR

An objective of the present invention is to provide a novel NDM (New Delhi metallo-β-lactamase) inhibitor that functions as a drug for restoring the antibacterial activity of β-lactam antibiotics that have been inactivated as a result of decomposition by NDM. According to the present invention, there is provided an NDM inhibitor contains a compound represented by general formula (I):

Metallo-beta-lactamase inhibitors

A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.