929606-98-4Relevant academic research and scientific papers
Facile synthesis of pyrazoles by iron-catalyzed regioselective cyclization of hydrazone and 1,2-diol under ligand-free conditions
Panda, Niranjan,Ojha, Subhadra
, p. 244 - 251 (2018/03/13)
A facile synthesis of pyrazoles by the cyclization of hydrazones and 1,2-diols was described. In the presence of ferric nitrate, the reaction occurs under neat conditions and makes the use of potassium persulfate to oxidize the diol to α-hydroxy carbaldehyde for the reaction with hydrazones to produce 1,3- and 1,3,5-substituted pyrazoles selectively. The overall regioselective transformation occurs in one-pot under ligand-free, mild conditions even in the presence of air.
Highly regioselective synthesis of 1-aryl-3,4,5-substituted pyrazoles
Gosselin, Francis,O'Shea, Paul D.,Webster, Robert A.,Reamer, Robert A.,Tillyer, Richard D.,Grabowski, Edward J. J.
, p. 3267 - 3270 (2008/09/17)
A highly regioselective synthesis of 1-aryl-3,4,5-substituted pyrazoles based on the condensation of 1,3-diketones with arylhydrazines is described. The reaction proceeds at room temperature in N,N-dimethylacetamide and furnishes pyrazoles in 59-98% yield
