929617-32-3 Usage
Uses
Used in Chemical Research:
5-bromo-3-chloro-6-nitro-1H-indazole is used as a research compound for exploring its chemical properties and potential interactions with other compounds. Its unique structure allows scientists to investigate its reactivity, stability, and possible applications in various chemical processes.
Used in Pharmaceutical Development:
5-bromo-3-chloro-6-nitro-1H-indazole is used as a starting material or intermediate in the synthesis of pharmaceutical compounds. Its complex structure and functional groups can be utilized to develop new drugs with specific therapeutic properties, such as antimicrobial, anticancer, or anti-inflammatory agents.
Used in Material Science:
5-bromo-3-chloro-6-nitro-1H-indazole is used as a component in the development of new materials with unique properties. Its incorporation into polymers, coatings, or other materials can lead to improved performance, such as enhanced stability, increased resistance to degradation, or specific optical or electronic properties.
Used in Analytical Chemistry:
5-bromo-3-chloro-6-nitro-1H-indazole is used as a reference compound or standard in analytical chemistry. Its distinct chemical properties can be employed to calibrate instruments, validate analytical methods, or as a benchmark for comparing the performance of different analytical techniques.
Used in Environmental Applications:
5-bromo-3-chloro-6-nitro-1H-indazole is used as a tracer or indicator in environmental studies. Its unique chemical signature can be employed to track the movement of pollutants, monitor the effectiveness of remediation efforts, or study the behavior of chemicals in the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 929617-32-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,9,6,1 and 7 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 929617-32:
(8*9)+(7*2)+(6*9)+(5*6)+(4*1)+(3*7)+(2*3)+(1*2)=203
203 % 10 = 3
So 929617-32-3 is a valid CAS Registry Number.
929617-32-3Relevant academic research and scientific papers
NOVEL COMPOUNDS THAT ARE ERK INHIBITORS
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Page/Page column 90-91, (2014/11/13)
Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (I).
Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt
Zhu, Gui-Dong,Gong, Jianchun,Gandhi, Viraj B.,Woods, Keith,Luo, Yan,Liu, Xuesong,Guan, Ran,Klinghofer, Vered,Johnson, Eric F.,Stoll, Vincent S.,Mamo, Mulugeta,Li, Qun,Rosenberg, Saul H.,Giranda, Vincent L.
, p. 2441 - 2452 (2007/10/03)
Thr-211 is one of three different amino acid residues in the kinase domain of protein kinase B/Akt as compared to protein kinase A (PKA), a closely related analog in the same AGC family. In an attempt to improve the potency and selectivity of our indazole-pyridine series of Akt inhibitors over PKA, efforts have focused on the incorporation of a chemical functionality to interact with the hydroxy group of Thr-211. Several substituents including an oxygen anion, amino, and nitro groups have been introduced at the C-6 position of the indazole scaffold, leading to a significant drop in Akt potency. Incorporation of a nitrogen atom into the phenyl ring at the same position (i.e., 9f) maintained the Akt activity and, in some cases, improved the selectivity over PKA. The structure-activity relationships of the new pyridine-pyrazolopyridine series of Akt inhibitors and their structural features when bound to PKA are also discussed.
