929635-71-2

Usage

Also known as

4-fluorophenyl-pyrazolyl-amine

Molecular weight

169.18 g/mol
Member of the pyrazole family
Commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds
Versatile building block that can undergo various chemical reactions to produce derivatives with different functional groups and properties
Important compound in medicinal chemistry with potential applications in drug discovery and development

InChI:InChI=1/C9H8FN3/c10-7-3-1-6(2-4-7)8-5-9(11)13-12-8/h1-5H,(H3,11,12,13)

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 205984-77-6 3-chloro-3-(4-fluorophenyl)acrylonitrile 
• 55338-97-1 β-chloro-β-(4-fluorophenyl)acrylaldehyde 
• 138716-37-7 5-(4-fluorophenyl)isoxazole 

Relevant academic research and scientific papers

Synthesis of Aminopyrazoles from Isoxazoles: Comparison of Preparative Methods by in situ NMR Analysis

A single-step method and a two-step method for the synthesis of aminopyrazoles from isoxazoles are presented and compared. Based on in situ NMR monitoring, both processes proceed through a ketonitrile. In the single-step process, hydrazine serves to both open the isoxazole to the unisolated ketonitrile intermediate and form the aminopyrazole. The two-step process involves ring opening of the isoxazole by deprotonation with hydroxide to generate the ketonitrile followed by the addition of acetic acid and hydrazine to form the aminopyrazole.

Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors

Two series comprising 20 novel benzenesulfonamides bearing thioureido-linked pyrazole 8 and amino-1,2,4-thiadiazole 10 were synthesized and assayed as human carbonic anhydrase (hCA) inhibitors against isoforms I and II as well as the tumor-associated isof

Polysubstituted heterocyclic derivative, preparation method thereof and application of polysubstituted heterocyclic derivative in medicine

The invention provides a polysubstituted heterocyclic derivative, a preparation method thereof and application of the polysubstituted heterocyclic derivative in medicine, and belongs to the technical field of medicinal chemistry. The polysubstituted heterocyclic derivative is a compound shown in a general formula I or II, a pharmaceutically acceptable salt or a solvate of the compound, and the compound can inhibit mRNA demethylase on the protease level and is used for treating diseases related to mRNA demethylase functions.