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Upstream product

• 96-36-6 methyl phosphite 
• 563-96-2 2,2-dihydroxyacetic acid 
• 64370-35-0 p-nitrobenzyl glyoxylate 
• 64-19-7 acetic acid 

Relevant academic research and scientific papers

Tandem Claisen condensation/transesterification between arylacetate enolates and arylmethylene-substituted 2,2-dimethyl-1,3-dioxolan-4-ones: An improved synthesis of z-configured pulvinones

Horner-Wadsworth-Emmons (HWE) alkenations of aromatic aldehydes with the novel phosphonate 24b led to E-configured arylmethylene-substituted 2,2-dimethyl-1,3-dioxolan-4-ones 25a-f (79-88% yield). The latter condensed with the lithium enolates of methyl arylacetates lithio-20b-d to give, after acid treatment and crystallization, isomerically pure (Z)-pulvinones 8d-s in 75-91% yield. We also showed that Horner-Wadsworth-Emmons reactions between phosphonate 24b and aliphatic aldehydes lead to E-configured alkylmethylene-substituted 2,2-dimethyl-1,3-dioxolan-4-ones 25g-i (82-96% yield). Georg Thieme Verlag Stuttgart.

4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them

New 4-substituted azetidinones having the formulea I and II: STR1 with R1, R2, R3, R4, R5 and X defined hereafter, which are intermediates for the preparation of carbapenem and carbacephem antibacterials and processes for producing such antibacterials through the utilization of an acid mediated ring closure reaction.