929917-69-1

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-(Hydroxymethyl)piperidine hydrochloride is used as a building block for the synthesis of various pharmaceuticals and drug candidates. Its unique structure and properties make it a valuable component in the development of new medications and therapeutic agents.
Used in Chemical Industry:
(R)-2-(Hydroxymethyl)piperidine hydrochloride is used as an intermediate in the production of chiral compounds. Chiral compounds have asymmetrical carbon atoms and are important in various chemical processes and applications. This chemical plays a crucial role in the synthesis of these compounds, contributing to the advancement of the chemical industry.

Upstream product

• 3105-95-1 pipecolinic acid 
• 157634-00-9 tert-butyl 2-(hydroxymethyl)piperidine-1-carboxylate 
• 134441-93-3 tert-butyl (2S)-2-(hydroxymethyl)piperidine-1-carboxylate 
• 851975-35-4 (S)-(+)-1-benzyloxy-N-benzyloxycarbonyl-N-but-3-enyl-2-but-3-enylamine 
• 851975-37-6 (S)-(+)-1-benzyloxy-N-but-3-enyl-2-but-3-enylamine 
• 851975-40-1 (S)-(-)-N-benzyloxycarbonyl-2-benzyloxymethyl-1,2,5,6-tetrahydropyridine 
• 134441-61-5 tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate 

Downstream Products

• 56098-75-0 1-(octahydro-pyrido[2,1-c][1,4]oxazepin-4-yl)-3-phenyl-propenone 
• 56098-74-9 (3-nitro-phenyl)-(octahydro-pyrido[2,1-c][1,4]oxazepin-4-yl)-methanone 
• 56189-36-7 1-benzoyloxy-1-(octahydro-pyrido[2,1-c][1,4]oxazepin-4-yl)-1-phenyl-ethane 
• 56099-10-6 (4-chloro-phenyl)-(4-methoxy-phenyl)-(octahydro-pyrido[2,1-c][1,4]oxazepin-4-yl)-methanol 
• 56099-09-3 (4-fluoro-phenyl)-(4-methoxy-phenyl)-(octahydro-pyrido[2,1-c][1,4]oxazepin-4-yl)-methanol 
• 56099-08-2 (4-dimethylamino-phenyl)-(octahydro-pyrido[2,1-c][1,4]oxazepin-4-yl)-phenyl-methanol 
• 56099-57-1 4-(4-chloro-4'-methoxy-benzhydrylidene)-octahydro-pyrido[2,1-c][1,4]oxazepine 
• 56099-07-1 octahydro-pyrido[2,1-c][1,4]oxazepin-4-yl-diphenyl-methanol 
• 56099-06-0 1-(octahydro-pyrido[2,1-c][1,4]oxazepin-4-yl)-1-phenyl-butan-1-ol 
• 56099-05-9 1-(octahydro-pyrido[2,1-c][1,4]oxazepin-4-yl)-1-phenyl-propan-1-ol 
• 56099-04-8 1-(octahydro-pyrido[2,1-c][1,4]oxazepin-4-yl)-1-phenyl-ethanol 
• 56189-35-6 (4-methoxy-phenyl)-(octahydro-pyrido[2,1-c][1,4]oxazepin-4-yl)-methanol 
• 56098-90-9 (4-chloro-phenyl)-(octahydro-pyrido[2,1-c][1,4]oxazepin-4-yl)-methanol 
• 864410-68-4 C₁₄H₁₉NO₃ 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS FOR PARASITE CONTROL

The present invention relates in its broadest aspect to a compound of Formula I as provided herein, formulations comprising such a compound and corresponding uses thereof for the reduction of infestation with ectoparasites, in particular ectoparasites of the insect class, including fleas and mosquitoes and/or ectoparasites of the arachnid class, including ticks and mites, etc. Also provided herein are methods for preparing the formulations of the invention and methods for controlling ectoparasites using the compounds and/or formulations provided herein.

AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF

The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I and Formula III, as described herein, and pharmaceutically acceptable salts thereof.

Amide derivative, preparation method of amide derivative, and application of amide derivative to pharmacy

The invention provides an amide derivative, a preparation method of the amide derivative, and application of the amide derivative to pharmacy. The amide derivative compound is selected from one of the following structures. The compound can be used for preparing medicines in the fields of local anaesthesia or analgesia. (The formulas are as shown in the description).

1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER

The invention relates to 1, 7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk 1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

SUBSTITUTED SULFONAMIDE DERIVATIVES

The invention relates to substituted sulfonamide derivatives of the general formula (I'); processes for their preparation, medicaments containing these compounds, and the use of substituted sulfonamide derivatives for the preparation of medicaments

BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION

The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula Ψ: An example is

Chiral oxime ethers in asymmetric synthesis. O-(1-Phenylbutyl)- benzyloxyacetaldoxime, a versatile reagent for the asymmetric synthesis of protected 1,2-aminoalcohols, α-amino acid derivatives, and 2-hydroxymethyl nitrogen heterocycles including iminosugars

Addition of a range of organolithium and Grignard reagents to (E)-O-(1-phenylbutyl)benzyloxyacetaldoxime 1 in the presence of boron trifluoride dietbyl etherate is highly diastereoselective. The resulting hydroxylamines 2 undergo N-O bond cleavage upon treatment with zinc-acetic acid or molybdenum hexacarbonyl to give, after N-protection, protected 1,2-aminoalcohols 3 in high enantiomeric purity. Debenzylation of 3a and 3d gave N-Boc (R)-alaninol and (S)-phenylalaninol respectively. The hydroxylamines 2 also serve as α-amino acid precursors, 2i being converted into N-formyl-(R)-alaninyl-(S)-(4-bromo)phenylalanine ester 7, the N-terminal dipeptide of a natural depsipeptide. The versatility of the 1,2-aminoalcohol derivatives was further illustrated by their conversion into 5-, 6- and 7-membered 2-hydroxymethyl nitrogen heterocycles 15-19 in high enantiomeric excess by a ring-closing metathesis reaction. Further reaction of the dihydropyrrole 15 gave the iminosugar 1,4-dideoxy-1,4-imino-D-ribitol. The Royal Society of Chemistry 2005.