93-00-5

Usage

Uses

Used in Pharmaceutical Industry:
6-Amino-2-naphthalenesulfonic acid is used as a key intermediate in the synthesis of diaryl urea derivatives bearing a sulfonamide moiety. These derivatives exhibit in vitro antitumor activity, making them valuable for the development of new cancer treatments.
In the pharmaceutical industry, 6-Amino-2-naphthalenesulfonic acid plays a crucial role in the development of novel therapeutic agents with potential antitumor properties. Its unique chemical structure allows for the creation of diaryl urea derivatives that can target and inhibit the growth of cancer cells, offering a promising avenue for cancer research and treatment.

Flammability and Explosibility

Notclassified

Purification Methods

Crystallise the acid from a large volume of hot water. The diethylamine salt has m 190.5-192o (from EtOH/isoBuOH), and the S-benzylisothiuronium salt has m 330o (from nBuOH). [Beilstein 14 H 760, 14 II 463, 14 III 2249, 14 IV 2804.]

InChI:InChI=1/C10H9NO3S/c11-9-3-1-8-6-10(15(12,13)14)4-2-7(8)5-9/h1-6H,11H2,(H,12,13,14)/p-1

Upstream product

• 86-60-2 7-aminonaphthalene-1-sulfonic acid 
• 81-05-0 6-aminonaphthalene-1-sulfonic acid 
• 117-62-4 2-amino-1,5-naphthalenedisulfonic acid 
• 93-01-6 2-naphthol-6-sulfonic acid 
• 91-59-8 naphthalen-2-ylamine 
• 7664-41-7 ammonia 
• 7664-93-9 sulfuric acid 
• 7446-11-9 sulfur trioxide 
• 81-16-3 2-aminonaphthalenesulfonic acid 
• 15509-36-1 3-hydroxy-7-sulfo-[2]naphthoic acid 
• 74631-01-9 [2]naphthylamine; sulfate 
• 135-19-3 β-naphthol 

Downstream Products

• 7724-15-4 6-p-toluidinonaphthalene-2-sulfonic acid 
• 109594-35-6 2-(4-amino-phenyl)-naphtho[2,1-d]thiazole-7-sulfonic acid 
• 20096-53-1 2-anilinonaphthalene-6-sulfonic acid 
• 855284-29-6 benzo[f]quinoline-8-sulfonic acid 
• 6481-89-6 6-amino-5-phenylazo-naphthalene-2-sulfonic acid 
• 6838-02-4 2-amino-naphthalene-1,6-disulfonic acid 
• 86-65-7 2-aminonaphthalene-6,8-disulfonate 
• 57189-62-5 6-Brom-2-naphthalinsulfonsaeure 
• 102878-14-8 6-chloro-2-naphthalenesulphonic acid 
• 93-01-6 2-naphthol-6-sulfonic acid 
• 132-34-3 3-amino-4-[4'-(2-amino-6-sulfo-[1]naphthylazo)-3,3'-dimethyl-biphenyl-4-ylazo]-naphthalene-2,7-disulfonic acid 
• 123289-89-4 6-(4-tert-butylphenylamino)-naphthalene-2-sulfonic acid 

Relevant academic research and scientific papers

Triphendioxazine dyestuffs

The novel triphendioxazine dyestuffs of the formula STR1 in which the substituents R, R', T1, T2, X, Y and n have the meanings given in the description are highly suitable for the dyeing and printing of cellulose-containing or amido-containing material.

Single-vessel process for preparing 2-acetaminonaphthalene-6-sulfonic acid of high purity

A single-vessel process for preparing 2-acetaminonaphthalene-6-sulfonic acid of high purity by sulfonating 2-hydroxynaphthalene with concentrated sulfuric acid, converting the 2-hydroxynaphthalenesulfonic acid formed with ammonia in the presence of ammonium hydrogensulfite into 2-amino-naphthalene-6-sulfonic acid (Bucherer reaction) and N-acetylating the latter to give 2-acetaminonaphthalene-6-sulfonic acid, which comprises, after diluting the sulfonating melt with water, substantially removing any impurities still present in the resulting aqueous solution of 2-hydroxynaphthalene-6-sulfonic acid, in particular 2-hydroxynaphthalene, by extraction with toluene or xylene and/or clarification using active carbon.

Reactive dye having both monochlorotriazinyl and vinylsulfone type reactive groups

A novel reactive monoazo dye, capable of giving cellulose fiber materials a deep orange to scarlet color and superior in build-up and chlorine fastness properties, represented by a free acid of the formula, STR1 wherein R1 is hydrogen, methyl or ethyl; R2 is an alkyl having 1 to 4 carbons that is either unsubstituted or substituted with hydroxy, cyano, alkoxy, halogen, carboxy, alkoxycarbonyl or sulfonic acid; Z is hydrogen or sulfonic acid; A is phenylene and is either unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of methyl, ethyl, methoxy, ethoxy, chlorine, bromine and sulfonic acid, or natphthylene that is either unsubstituted or substituted with sulfonic acid; X is --SO2 CH=CH2 or --SO2 CH2 CH2 Y in which Y is a group that is splittable by alkalis; and m is an integer of 1 to 3.

Fiber reactive monoazo compounds having two vinylsulfone type fiber reactive groups in the molecule

A monoazo compound of the following formula in a free acid form, STR1 wherein A1 and A2 are phenylene or naphthylene, Z1 and Z2 are --SO2 CH=CH2 or --SO2 CH2 CH2 Y in which Y is a splittable group, R1 and R2 are hydrogen or alkyl, and D is sulfophenyl or sulfonaphthyl, provided that --A1 --Z1 and --A2 --Z2 are different from each other when D is sulfophenyl and both R1 and R2 are hydrogen, which is useful for dyeing or printing fiber materials to give dyed products of high fastness properties with extremely high color depth.

Solid phase acylation of aminosulfonic acids

This invention is directed to the acylation of aminosulfonic acids in the solid phase. Two discrete, sequential chemical reactions occur, i.e. (1) the neutralization of the aminosulfonic acid, and (2) the subsequent amine acylation, to produce an improved neutralized acyl-aminosulfonic acid at a reduced cost. Aminosulfonic acids having the general formula HO3 S-A-NH2 are acylated to neutralized acyl-aminosulfonic acids having the general formula RCONH-A-SO3 M, where A is an unsubstituted or substituted aliphatic, aromatic or heteroaromatic group and M is a neutralizing agent moiety. The yield is virtually quantitative.

Fiber-reactive disazo brown dye having vinylsulfone-type reactive group

A compound, or a salt thereof, represented by the following formula, STR1 wherein A is a substituted or unsubstituted phenylene or naphthylene group, B is STR2 in which R3 is a hydrogen atom or a lower alkyl, lower alkoxy, acylamino or ureido group, and R4 is a hydrogen atom or a lower alkyl or lower alkoxy group, R1 and R3 are independently a hydrogen atom or a substituted or unsubstituted lower alkyl group, X is a substituted or unsubstituted amino, lower alkoxy, substituted phenoxy or sulfo group, Y is --SO2 CH=CH2 or --SO2 CH2 CH2 Z, in which Z is a group capable of being split by the action of an alkali, and m is 2 or 3, which is useful for dyeing hydroxyl group- or amide group-containing fiber materials to give dyed products of a brown color having excellent fastness properties with good build-up property.