93-45-8 Usage
Chemical Properties
purple solid
Air & Water Reactions
N-(4-HYDROXYPHENYL)-2-NAPHTHYLAMINE, 97 may be sensitive to prolonged exposure to air. Insoluble in water.
Reactivity Profile
Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition N-(4-HYDROXYPHENYL)-2-NAPHTHYLAMINE, 97 emits toxic fumes.
Fire Hazard
Flash point data for N-(4-HYDROXYPHENYL)-2-NAPHTHYLAMINE, 97 are not available, however, N-(4-HYDROXYPHENYL)-2-NAPHTHYLAMINE, 97 is probably combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 93-45-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 3 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 93-45:
(4*9)+(3*3)+(2*4)+(1*5)=58
58 % 10 = 8
So 93-45-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H13NO/c18-16-9-7-14(8-10-16)17-15-6-5-12-3-1-2-4-13(12)11-15/h1-11,17-18H
93-45-8Relevant articles and documents
Copper(ii)-catalyzed Chan-Lam cross-coupling: chemoselective N-arylation of aminophenols
Siva Reddy,Ranjith Reddy,Nageswar Rao,Jaladanki, Chaitanya K.,Bharatam, Prasad V.,Lam, Patrick Y. S.,Das, Parthasarathi
supporting information, p. 801 - 806 (2017/02/05)
Copper(ii)-catalyzed boronic acid promoted chemoselective N-arylation of unprotected aminophenols has been developed. Selective N-arylation of 3-aminophenol is achieved with a Cu(OAc)2/AgOAc combination in MeOH at rt, whereas the chemoselective N-arylated products of 4-aminophenol can be obtained with a Cu(OAc)2/Cs2CO3 system and benzoic acid as an additive. These ligand-free conditions and “open-flask” chemistry are robust and compatible with a wide range of functional groups. The mechanistic investigation for this selective N-arylation has been studied by considering Density Functional Theory (DFT) calculations.
Method of inhibiting leukotriene biosynthesis by oral administration of p-aminophenols or derivatives thereof
-
, (2008/06/13)
A method is provided for inhibiting leukotriene biosynthesis and thus treating asthma, psoriasis or inflammation by oral administration of p-aminophenols having the structure STR1 wherein m is 0 to 5; X is CH or N; R1 and R2 may be the same or different and are H, lower alkyl, aryl, hydroxy, hydroxyalkyleneoxy, alkylthio, alkoxy, alkanoyloxy, aryloxy, halo, carboxy, alkoxycarbonyl or amido; R3 is H, lower alkyl, alkanoyl or aroyl; and R4 is H, lower alkyl, benzoyl or alkanoyl, and including acid-addition salts thereof, with the proviso that when R4 is benzoyl, R2 is other than H.
