93007-95-5Relevant academic research and scientific papers
Nickel-Catalyzed Regio- And Stereospecific C-H Coupling of Benzamides with Aziridines
Hirano, Koji,Miura, Masahiro,Xu, Shibo
, p. 5471 - 5475 (2021/07/26)
A nickel-catalyzed C-H coupling of 8-aminoquinoline-derived benzamides with aryl- and alkyl-substituted aziridines has been disclosed. The current strategy provides direct access to benzolactams by the C-H alkylation-intramolecular amidation cascade event with the concomitant removal of the aminoquinoline auxiliary. The regioselectivity of ring opening of aziridines can be controlled by the substituents. The reaction with chiral aziridines proceeds with inversion of configuration, thus suggesting an SN2-type nucleophilic ring-opening pathway.
A method for synthesizing the chiral anti-form yinyin amine is mellow (by machine translation)
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Paragraph 0012; 0014; 0016, (2017/08/02)
The invention discloses a method for synthesizing the chiral anti-form yinyin amine is mellow. by yin as raw materials, the sodium tungstate/phase transfer catalyst/hydrogen peroxide system to reaction ring oxidation, then reaction with benzylamine, split through the mandelic acid, hydrogenated to obtain ≥ 98% ee the anti-form yinyin amine is mellow. The method uses and is simple, easy to operate, compared to the previous resolution method, more easy to realize the amplifying production. (by machine translation)
Targeting multimeric imaging agents through multilocus binding
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, (2008/06/13)
The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon binding to endogenous proteins or other physiologically relevant
