93010-73-2

Upstream product

• 609-65-4 o-chlorobenzoyl chloride 
• 60-15-1 2-amino-1-phenylpropane 
• 118-91-2 ortho-chlorobenzoic acid 

Downstream Products

• 439614-61-6 1-(2-chlorophenyl)-3-hydroxymethylisoquinoline 
• 439614-64-9 1-(2-chlorophenyl)-3-methylisoquinoline N-oxide 
• 439614-60-5 1-(2-chlorophenyl)isoquinoline-3-carboxaldehyde 
• 89242-09-1 1-(2-chlorophenyl)-3-isoquinolinecarboxylic acid 
• 92853-34-4 1-(2-chlorophenyl)-3-methylisoquinoline 
• 92874-45-8 1-(2-chlorophenyl)-3-methyl-3,4-dihydroisoquinoline 
• 873-32-5 2-Chlorobenzonitrile 

Relevant academic research and scientific papers

Synthetic approaches to 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid

In connection with our research of new antitumor compounds, previously undescribed approaches to the 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid 9 are reported here. Two related accesses from phenylethylamine or amphetamine were investigated and were found to be successful. A more robust synthesis, using Suzuki's cross-coupling between 2-chlorophenylboronic acid 15 and the previously unreported methyl-1-bromoisoquinoline-3-carboxylate 14 was also developed. This synthetic route provides the ground for a combinatorial approach to the core structure of new potential peripheral benzodiazepine receptor ligands.

o-CHLOROTHIOBENZAMIDES AS ADDITIVES TO LUBRICATING OILS.

The authors report the results of synthesis of o-chlorothiobenzamides and of a study of their properties as lubricant additives. The results of tests of the anticorrosion properties of o-chlorothiobenzamides were compared with the results of tests on compounds of analogous structure: thiobenzamides and o-chlorobenzamides. The results show that o-chlorothiobenzamides added to DS-11 oil have definite anticorrosion and antiwear effects, manifested in decrease of the degree of corrosion and of the diameter of the wear patch (D//p).