930113-27-2Relevant academic research and scientific papers
Cobalt-Catalyzed Direct Arylation of Imidazo[1,2-a]pyridine with Aryl Iodides
Babar, Dattatraya A.,Rode, Haridas B.
supporting information, p. 1823 - 1827 (2020/03/23)
The Co(II)Cl2·6H2O catalyzed C–H activation/direct arylation of imidazo[1,2-a]pyridine with aryl/heteroaryl iodide is reported. The cost effective, ligand and additive free protocol using KOAc successfully afforded 3-arylimidazo[1,2-
Facile synthesis of 3-substituted imidazo[1,2-: A] pyridines through formimidamide chemistry
Sivappa, Rasapalli,Sammeta, Vamshikrishna Reddy,Huang, Yanchang,Golen, James A.,Savinov, Sergey N.
, p. 29659 - 29664 (2019/10/01)
A facile entry to 3-aryl/alkenyl/alkynyl substituted imidazo[1,2-a]pyridines (3a-p, 6a-d & 9a-9e) has been developed from readily available benzyl/allyl/propargyl halides and 2-amino pyridines as substrates via formimidamide chemistry that is devoid of caustic or expensive reagents, such as transition metal complexes. Quantum chemical calculations performed to understand the underlying mechanism of the transformation revealed a preference for intramolecular Mannich-type addition over pericyclic 1,5-electrocyclization for the systems reported herein that enable a Baldwin allowed 5-exo-trig cyclization instead of a formally anti-Baldwin 5-endo-trig process.
Highly regioselective palladium-catalyzed direct cross-coupling of imidazo[1,2-a]pyridines with arylboronic acids
Zhao, Limin,Zhan, Haiying,Liao, Jinqiang,Huang, Jianping,Chen, Qinlin,Qiu, Huifang,Cao, Hua
, p. 65 - 67 (2014/08/18)
A highly regioselective method for the palladium-catalyzed direct cross-coupling of imidazo[1,2-a]pyridines with arylboronic acids has been developed by using O2 as oxidant. This process can be applied to a wide range of imidazo[1,2-a]pyridines and arylboronic acids with excellent C-3-regioselectivity. It provides a new way for developing CC bond-forming processes of multisubstituted imidazo[1,2-a]pyridines, which are common structural motifs in natural products and pharmaceuticals.
Rhodium-catalyzed highly regioselective C-H arylation of imidazo[1,2-a]pyridines with aryl halides and triflates
Liu, Yi,He, Lin,Yin, Guoqiang,Wu, Guojie,Cui, Yingde
, p. 2340 - 2342 (2013/09/24)
A convenient Rh-catalyzed C-H arylation of imidazo[1,2-a]pyridines with a variety of aryl halides or triflates has been reported. This process afforded a range of biaryl compounds in excellent yields and showed high activity and broad scope.
Synthesis of 3-arylimidazo[1,2-a]pyridines by a catalyst-free cascade process
Wu, Zhiqing,Pan, Yinyin,Zhou, Xiangge
supporting information; experimental part, p. 2255 - 2260 (2011/09/15)
A simple and efficient protocol to synthesize 3-arylimidazo[1,2-a]pyridines by a catalyst-free cascade process from 2-aminopyridine and 1-bromo-2-phenylacetylene or 1,1-dibromo-2-phenylethene in yields up to 86% is described. Georg Thieme Verlag Stuttgart ? New York.
Regioselective palladium-catalyzed arylation and heteroarylation of imidazo[1,2-a]pyridines
Koubachi, Jamal,El Kazzouli, Sa?d,Berteina-Raboin, Sabine,Mouaddib, Abderrahim,Guillaumet, Gérald
, p. 3237 - 3242 (2008/09/17)
Palladium-catalyzed direct arylation and heteroarylation of imidazo[1,2-a]pyridines at the 3-position are described. The optimization of the reaction in conventional heating and the adaptation under microwaves irradiation is reported. The compatibility of
