930587-83-0Relevant academic research and scientific papers
Parallel synthesis and SAR study of novel oxa-steroids as potent and selective progesterone receptor antagonists
Kang, Fu-An,Guan, Jihua,Jain, Nareshkumar,Allan, George,Linton, Olivia,Tannenbaum, Pamela,Chen, Xin,Xu, Jun,Zhu, Peifang,Gunnet, Joseph,Demarest, Keith,Lundeen, Scott,Sui, Zhihua
, p. 2531 - 2534 (2007)
Efficient parallel synthesis of novel 7-oxa-steroids 4 has been achieved from the key intermediate 3 via a one-pot four-step sequence. oxa-Steroids 4 with various ortho-, meta-, and para-monosubstituents on the phenyl ring, as well as disubstituted phenyl
Synthesis and identification of novel oxa-steroids as progesterone receptor antagonists
Kang, Fu-An,Allan, George,Guan, Jihua,Jain, Nareshkumar,Linton, Olivia,Tannenbaum, Pamela,Xu, Jun,Zhu, Peifang,Gunnet, Joseph,Chen, Xin,Demarest, Keith,Lundeen, Scott,Sui, Zhihua
, p. 907 - 910 (2007/10/03)
A novel series of oxa-steroids 6 derived from (8S, 13S, 14R)-7-oxa-estra-4,9-diene-3,17-dione 1 have been synthesized and identified as potent and selective progesterone receptor antagonists. These novel oxa-steroids showed similar potency to mifepristone
OXA-STEROIDS DERIVATIVES AS SELECTIVE PROGESTERONE RECEPTOR MODULATORS
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Page/Page column 15, (2010/11/28)
The present invention is directed to novel 7-oxa-estra-4,9-diene-3,17-dione derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by at least one progesterone or glucocorticoid recept
